Japanese encephalitis

Indication: Vaccination provides protection against Japanese encephalitis. Vaccination is recommended if you intend to spend more than three to four weeks in a region where the disease is prevalent.

Vaccination: You need two injections at an interval of about two weeks, and the vaccination now provides protection for one year. A third vaccination administered one year later extends protection to three years.

Protection: The vaccine does not give 100 per cent protection, so it is no alternative to ordinary protection against mosquito bites.

Side effects include:

• Redness around injection site
• Hardening of skin around injection site
• Weakness
• Fever
• Head aches

Japanese Encephalitis Vaccination Resource:

The estimated mortality impact of vaccinations forecast to be administered during 2011-2020 in 73 countries supported by the GAVI Alliance.
Lee LA, Franzel L, Atwell J, Datta SD, Friberg IK, Goldie SJ, Reef SE, Schwalbe N, Simons E, Strebel PM, Sweet S, Suraratdecha C, Tam Y, Vynnycky E, Walker N, Walker DG, Hansen PM.
Vaccine. 2013 Apr 18;31 Suppl 2:B61-72. doi: 10.1016/j.vaccine.2012.11.035
The history of vaccination and current vaccination policies in Korea.
Cha SH.
Clin Exp Vaccine Res. 2012 Jul;1(1):3-8. doi: 10.7774/cevr.2012.1.1.3. Epub 2012 Jul 31
A Survey of US Travelers to Asia to Assess Compliance With Recommendations for the Use of Japanese Encephalitis Vaccine.
Duffy MR, Reed C, Edelson PJ, Blumensaadt S, Crocker K, Griggs A, Biggerstaff BJ, Delorey MJ, Hayes EB, Fischer M.
J Travel Med. 2013 May;20(3):165-70. doi: 10.1111/jtm.12020. Epub 2013 Mar 8
A 44-year-old patient with a new-onset seizure disorder after vaccination against Japanese encephalitis: a case report.
Schulze C.
J Med Case Rep. 2013 Mar 12;7(1):66. [Epub ahead of print
The interactions of ethical notions and moral values of immediate stakeholders of immunisation services in two Indian states: a qualitative study.
Varghese J, Raman Kutty V, Ramanathan M.
BMJ Open. 2013 Mar 1;3(3). doi:pii: e001905. 10.1136/bmjopen-2012-001905. Print 2013
A threshold method for immunological correlates of protection.
Chen X, Bailleux F, Desai K, Qin L, Dunning AJ.
BMC Med Res Methodol. 2013 Mar 1;13(1):29. [Epub ahead of print
The dominant roles of ICAM-1-encoding gene in DNA vaccination against Japanese encephalitis virus are the activation of dendritic cells and enhancement of cellular immunity.
Zhai YZ, Zhou Y, Ma L, Feng GH.
Cell Immunol. 2013 Jan;281(1):1-10. doi: 10.1016/j.cellimm.2013.01.005. Epub 2013 Jan 29
Molecular detection and genotyping of Japanese encephalitis virus in mosquitoes during a 2010 outbreak in the Republic of Korea.
Seo HJ, Kim HC, Klein TA, Ramey AM, Lee JH, Kyung SG, Park JY, Cho YS, Cho IS, Yeh JY.
PLoS One. 2013;8(2):e55165. doi: 10.1371/journal.pone.0055165. Epub 2013 Feb 4
[Epidemic characteristics and viral antibody level among healthy people of Japanese B encephalitis in Henan province in 2010].
Tang XY, Kang K, Shang SY, Xu C, Li XL, Ma HX, Chen HM, Xu BL.
Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Oct;46(10):888-91. Chinese.
Recurrence of Japanese encephalitis epidemic in Wuhan, China, 2009-2010.
Hu Q, Chen B, Zhu Z, Tian J, Zhou Y, Zhang X, Zheng X.
PLoS One. 2013;8(1):e52687. doi: 10.1371/journal.pone.0052687. Epub 2013 Jan 9
Changing landscape of acute encephalitis syndrome in India: a systematic review.
Joshi R, Kalantri SP, Reingold A, Colford JM Jr.
Natl Med J India. 2012 Jul-Aug;25(4):212-20. Review
Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
Marks F, Nguyen TT, Tran ND, Nguyen MH, Vu HH, Meyer CG, You YA, Konings F, Liu W, Wierzba TF, Xu ZY.
PLoS Negl Trop Dis. 2012;6(12):e1952. doi: 10.1371/journal.pntd.0001952. Epub 2012 Dec 13
[Case report; a case of systemic lupus erythematosus complicated with limbic encephalitis after vaccination for influenza virus].
Kikuchi S, Sato M, Otaka Y, Takahashi Y, Watanabe T, Goda F.
Nihon Naika Gakkai Zasshi. 2012 Oct 10;101(10):2952-4. Japanese. No abstract available.
Vaccinating against Japanese encephalitis virus: what have we learned from recent clinical trials?
Dubischar-Kastner K, Kanesa-Thasan N.
Expert Rev Vaccines. 2012 Oct;11(10):1159-61. doi: 10.1586/erv.12.100. No abstract available.
Molecular evidence for the occurrence of Japanese encephalitis virus genotype I and III infection associated with acute encephalitis in patients of West Bengal, India, 2010.
Sarkar A, Taraphdar D, Mukhopadhyay SK, Chakrabarti S, Chatterjee S.
Virol J. 2012 Nov 15;9:271. doi: 10.1186/1743-422X-9-271
Adverse events following immunisation with SA 14-14-2 Japanese encephalitis vaccine in children of Kolar in Karnataka.
Ranganath BG, Hiremath SG.
J Indian Med Assoc. 2012 Jan;110(1):10-2
Partially neutralizing potency against emerging genotype I virus among children received formalin-inactivated Japanese encephalitis virus vaccine.
Fan YC, Chen JM, Chiu HC, Chen YY, Lin JW, Shih CC, Chen CM, Chang CC, Chang GJ, Chiou SS.
PLoS Negl Trop Dis. 2012;6(9):e1834. doi: 10.1371/journal.pntd.0001834. Epub 2012 Sep 27
Evaluation of Japanese encephalitis virus polytope DNA vaccine candidate in BALB/c mice.
Kulkarni R, Sapkal G, Gore M.
Virus Res. 2012 Dec;170(1-2):118-25. doi: 10.1016/j.virusres.2012.09.006. Epub 2012 Sep 21
Flaviviruses and their antigenic structure.
Heinz FX, Stiasny K.
J Clin Virol. 2012 Dec;55(4):289-95. doi: 10.1016/j.jcv.2012.08.024. Epub 2012 Sep 21. Review
Multiple linear epitopes (B-cell, CTL and Th) of JEV expressed in recombinant MVA as multiple epitope vaccine induces a protective immune response.
Wang F, Feng X, Zheng Q, Hou H, Cao R, Zhou B, Liu Q, Liu X, Pang R, Zhao J, Deng W, Chen P.
Virol J. 2012 Sep 17;9:204. doi: 10.1186/1743-422X-9-204
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