Synthesis and biological evaluation of indolyl chalcones as antitumor agents.

Authors: Kumar D,Kumar NM,Akamatsu K,Kusaka E,Harada H,Ito T,
Address: Birla Institute of Technology and Science, Pilani, India. dalipk@bits-pilani.ac.in
Journal: Bioorg Med Chem Lett.

Publication: 2010 Jul 1;20(13):3916-9. doi: 10.1016/j.bmcl.2010.05.016. Epub 2010 May 13.

abstract

A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively.

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