Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study.

Authors:
Address: Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain.
Journal:

Publication:

abstract

BACKGROUND:

the aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake.

METHODS/PRINCIPAL FINDINGS:

We conducted a hospital-based case-control study covering 215 UGIB cases and 650 controls. Odds ratios (ORs) with their confidence intervals (95% CIs) were calculated, as well as the ratio of the combined effects to the sum of the separate effects of Anisakis allergic sensitization and NSAIDs intake. Prior Anisakis infections were revealed by the presence of anti-Anisakis IgE antibodies specific to the recombinant Ani s 1 and Ani s 7 allergens used as the targets in indirect ELISA. Prior Anisakis infections (OR 1.74 [95% CI: 1.10 to 2.75]) and the intake of NSAIDs (OR 6.63 [95% CI: 4.21 to 10.43]) increased the risk of bleeding. Simultaneous NSAIDs intake and Anisakis allergic sensitization increased the risk of UGIB 14-fold (OR=14.46 [95% CI: 6.08 to 34.40]). This interaction was additive, with a synergistic index of 3.01 (95% CI: 1.18-7.71).

CONCLUSIONS:

Prior Anisakis infection is an independent risk factor for UGIB, and the joint effect with NSAIDs is 3 times higher than the sum of their individual effects.

Related Articles
Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay.
Clin Vaccine Immunol. 2010
Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay.
Anadón AM, Rodríguez E, Gárate MT, Cuéllar C, Romarís F, Chivato T, Rodero M, González-Díaz H, Ubeira FM. Clin Vaccine Immunol. 2010 Apr; 17(4):496-502. Epub 2010 Jan 27.
Digestive haemorrhage in patients with anti-Anisakis antibodies.
Eur J Gastroenterol Hepatol. 2...
Digestive haemorrhage in patients with anti-Anisakis antibodies.
Gutiérrez-Ramos R, Guillén-Bueno R, Madero-Jarabo R, Cuéllar del Hoyo C. Eur J Gastroenterol Hepatol. 2000 Mar; 12(3):337-43.
Helicobacter pylori and bleeding duodenal ulcer: prevalence of the infection and role of non-steroidal anti-inflammatory drugs.
Scand J Gastroenterol. 2001
Helicobacter pylori and bleeding duodenal ulcer: prevalence of the infection and role of non-steroidal anti-inflammatory drugs.
Gisbert JP, Gonzalez L, de Pedro A, Valbuena M, Prieto B, Llorca I, Briz R, Khorrami S, Garcia-Gravalos R, Pajares JM. Scand J Gastroenterol. 2001 Jul; 36(7):717-24.
Review Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s.
Arch Intern Med. 2000
Review Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s.
Hernández-Díaz S, Rodríguez LA. Arch Intern Med. 2000 Jul 24; 160(14):2093-9.
Review Anisakis simplex: sensitization and clinical allergy.
Curr Opin Allergy Clin Immunol...
Review Anisakis simplex: sensitization and clinical allergy.
Daschner A, Pascual CY. Curr Opin Allergy Clin Immunol. 2005 Jun; 5(3):281-5.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.