Protective role of antibodies induced by Brucella melitensis B115 against B. melitensis and Brucella abortus infections in mice.
Authors: Adone R,Francia M,Pistoia C,Petrucci P,Pesciaroli M,Pasquali P,
Address: Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy. email@example.com
Publication: 2012 Jun 8;30(27):3992-5. doi: 10.1016/j.vaccine.2012.04.009. Epub 2012 Apr 20.
It has been demonstrated that antibodies specific for O-PS antigen of Brucella smooth strains are involved in the Protective immunity of brucellosis. Since the rough strain Brucella melitensis B115 was able to protect mice against wild Brucella strains brucellosis despite the lack of anti-OPS antibodies, in this study we evaluated the biological significance of antibodies induced by this strain, directed to antigens other than O-PS, passively tranferred to untreated mice prior to infection with Brucella abortus 2308 and B. melitensis 16M virulent strains. The protective ability of specific antisera collected from mice vaccinated with B. melitensis B115, B. abortus RB51 and B. abortus S19 strains was compared. The results indicated that antibodies induced by B115 were able to confer a satisfactory protection, especially against B. abortus 2308, similar to that conferred by the antiserum S19, while the RB51 antiserum was ineffective. These findings suggest that antibodies induced by B115 could act as opsonins as well as antibodies anti-O-PS, thus triggering more efficient internalization and degradation of bacteria within phagocytes. This is the first study assessing the efficacy of antibodies directed to antigens other than O-PS in the course of brucellosis infection.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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