Prevalence of antibodies and RNA genome of hepatitis E virus in a cohort of French immunocompromised.

Authors:
Address: Virology Dpt, Inserm U941-Paris 7 Diderot University, Saint-Louis Hospital-APHP, Paris, France. sarah.maylin@sls.aphp.fr
Journal:

Publication:

abstract

BACKGROUND:

Recently, cases of chronic hepatitis E have been identified in immunocompromised patients.

OBJECTIVES:

To evaluate the Prevalence of anti-HEV IgG antibodies and the persistence of HEV-RNA in sera of immunocompromised patients with regular follow-up at Saint-Louis Hospital in Paris, France.

STUDY DESIGN:

307 samples collected from 261 HIV-infected patients and 46 kidney transplant (KT)-patients were retrospectively tested for the presence of the following hepatitis E virus (HEV) infection markers: anti-HEV IgM antibodies, anti-HEV IgG antibodies, anti-HEV IgG avidity index, and HEV-RNA.

RESULTS:

Anti-HEV IgG positive serology was found in 4 HIV-infected patients (1.5%) and 3 KT-patients (6.5%), leading to an overall seroprevalence of 2.3%. HEV-RNA detection was not observed among 55 HIV-patients at higher risk of chronic HEV (<200 CD4 cells/mm(3), elevated alanine aminotransferase (ALT) levels, and/or positive anti-HEV antibodies) and among 44 KT-patients. None of the seven patients had anti-HEV IgM antibodies, thereby excluding any acute infection. The IgG avidity index confirmed past HEV infection among tested patients.

CONCLUSIONS:

The low seroprevalence observed in the Paris region does not warrant a systematic evaluation of HEV infection in immunocompromised patients. However, HEV infection must be examined as a possibility if unexplained increases in ALT should occur and after more common viral hepatitis infections are excluded.

Related Articles
Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels.
Virol J. 2011
Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels.
Sellier P, Mazeron MC, Tesse S, Badsi E, Evans J, Magnier JD, Sanson-Le-Pors MJ, Bergmann JF, Nicand E. Virol J. 2011 Apr 15; 8:171. Epub 2011 Apr 15.
Hepatitis E virus infection in patients infected with the human immunodeficiency virus.
J Med Virol. 2011
Hepatitis E virus infection in patients infected with the human immunodeficiency virus.
Kaba M, Richet H, Ravaux I, Moreau J, Poizot-Martin I, Motte A, Nicolino-Brunet C, Dignat-George F, Ménard A, Dhiver C, et al. J Med Virol. 2011 Oct; 83(10):1704-16.
Evaluation of anti-hepatitis E virus (HEV) immunoglobulin A in a serological screening for HEV infection.
J Gastroenterol. 2007
Evaluation of anti-hepatitis E virus (HEV) immunoglobulin A in a serological screening for HEV infection.
Elkady A, Tanaka Y, Kurbanov F, Hirashima N, Sugiyama M, Khan A, Kato H, Okumura A, Mizokami M. J Gastroenterol. 2007 Nov; 42(11):911-7. Epub 2007 Nov 22.
Occurrence of hepatitis E virus IgM, low avidity IgG serum antibodies, and viremia in sporadic cases of non-A, -B, and -C acute hepatitis.
J Med Virol. 2002
Occurrence of hepatitis E virus IgM, low avidity IgG serum antibodies, and viremia in sporadic cases of non-A, -B, and -C acute hepatitis.
Zhang JZ, Im SW, Lau SH, Chau TN, Lai ST, Ng SP, Peiris M, Tse C, Ng TK, Ng MH. J Med Virol. 2002 Jan; 66(1):40-8.
Sero-epidemiology of hepatitis E virus (HEV) in urban and rural children of North India.
Indian Pediatr. 2001
Sero-epidemiology of hepatitis E virus (HEV) in urban and rural children of North India.
Mathur P, Arora NK, Panda SK, Kapoor SK, Jailkhani BL, Irshad M. Indian Pediatr. 2001 May; 38(5):461-75.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.