The major Polysaccharide antigens of P. aeruginosa are the cell-wall lipopolysaccharides many of which have an acidic polysaccharide chain (O-antigen) rich in unusual amino sugars. The D-rhamnose-rich polysaccharide antigen common to many serologically distinct strains is also associated with the lipopolysaccharide. The high-molecular-weight polysaccharides with O-specificity are present in extracellular slime produced by strains isolated from the environmental and from the immunocompromised hosts. The extracellular antigenic polysaccharide of another type (bacterial alginate) is expressed by mucoid strains isolated from patients with cystic fibrosis. Serotype-specific immune responses after infection are directed at the lipopolysaccharides and these heat-stable antigens serve as the basis for differentiation of P. aeruginosa strains. Both the cell-wall antigens including conjugates of the O-polysaccharides with different proteins and the extracellular antigens have been used to prepare specific antibodies tested for protection against infections due to P. aeruginosa.
Related ArticlesReview Pseudomonas aeruginosa antigens as potential vaccines.FEMS Microbiol Rev. 1997
Review Pseudomonas aeruginosa antigens as potential vaccines.
Stanislavsky ES, Lam JS. FEMS Microbiol Rev. 1997 Nov; 21(3):243-77.
Biologic activities of antibodies to the neutral-polysaccharide component of the Pseudomonas aeruginosa lipopolysaccharide are blocked by O side chains and mucoid exopolysaccharide (alginate).Infect Immun. 1995
Biologic activities of antibodies to the neutral-polysaccharide component of the Pseudomonas aeruginosa lipopolysaccharide are blocked by O side chains and mucoid exopolysaccharide (alginate).
Hatano K, Goldberg JB, Pier GB. Infect Immun. 1995 Jan; 63(1):21-6.
Polysaccharide antigens of Pseudomonas aeruginosa.Rev Infect Dis. 1988
Polysaccharide antigens of Pseudomonas aeruginosa.
Pier GB. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 2:S337-40.
Somatic antigens of Pseudomonas aeruginosa. The structure of O-specific polysaccharide chains of the lipopolysaccharides from P. aeruginosa O1 (Lányi), O3 (Habs), O13 and O14 (Wokatsch), and the serologically related strain NCTC 8505.Eur J Biochem. 1986
Somatic antigens of Pseudomonas aeruginosa. The structure of O-specific polysaccharide chains of the lipopolysaccharides from P. aeruginosa O1 (Lányi), O3 (Habs), O13 and O14 (Wokatsch), and the serologically related strain NCTC 8505.
Knirel YA, Vinogradov EV, Shashkov AS, Wilkinson SG, Tahara Y, Dmitriev BA, Kochetkov NK, Stanislavsky ES, Mashilova GM. Eur J Biochem. 1986 Mar 17; 155(3):659-69.
Review Promises and pitfalls of Pseudomonas aeruginosa lipopolysaccharide as a vaccine antigen.Carbohydr Res. 2003
Review Promises and pitfalls of Pseudomonas aeruginosa lipopolysaccharide as a vaccine antigen.
Pier GB. Carbohydr Res. 2003 Nov 14; 338(23):2549-56.
Review Recent developments for Pseudomonas vaccines.Hum Vaccin. 2011
Review Recent developments for Pseudomonas vaccines.
Sharma A, Krause A, Worgall S. Hum Vaccin. 2011 Oct; 7(10):999-1011. Epub 2011 Oct 1.
UDP-glucuronic acid decarboxylases of Bacteroides fragilis and their prevalence in bacteria.J Bacteriol. 2011
UDP-glucuronic acid decarboxylases of Bacteroides fragilis and their prevalence in bacteria.
Coyne MJ, Fletcher CM, Reinap B, Comstock LE. J Bacteriol. 2011 Oct; 193(19):5252-9. Epub 2011 Jul 29.
Mucosal vaccination with a multivalent, live-attenuated vaccine induces multifactorial immunity against Pseudomonas aeruginosa acute lung infection.Infect Immun. 2011
Mucosal vaccination with a multivalent, live-attenuated vaccine induces multifactorial immunity against Pseudomonas aeruginosa acute lung infection.
Kamei A, Coutinho-Sledge YS, Goldberg JB, Priebe GP, Pier GB. Infect Immun. 2011 Mar; 79(3):1289-99. Epub 2010 Dec 13.
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