Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum.

Authors:
Address: Evolutionary Genomics and Bioinformatics Laboratory, Division of Genomics and Bioinformatics, National Institute of Malaria Research, New Delhi, India.
Journal:

Publication:

abstract

Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.

Related Articles
Population genetic analyses of Plasmodium falciparum chloroquine receptor transporter gene haplotypes reveal the evolutionary history of chloroquine-resistant malaria in India.
Int J Parasitol. 2011
Population genetic analyses of Plasmodium falciparum chloroquine receptor transporter gene haplotypes reveal the evolutionary history of chloroquine-resistant malaria in India.
Awasthi G, Prasad GB, Das A. Int J Parasitol. 2011 Jun; 41(7):705-9. Epub 2011 Apr 9.
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.
Antimicrob Agents Chemother. 2...
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.
Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, et al. Antimicrob Agents Chemother. 2008 Jun; 52(6):2212-22. Epub 2008 Apr 14.
Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea.
Malar J. 2007
Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea.
DaRe JT, Mehlotra RK, Michon P, Mueller I, Reeder J, Sharma YD, Stoneking M, Zimmerman PA. Malar J. 2007 Mar 21; 6:34. Epub 2007 Mar 21.
Review pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
Acta Trop. 2005
Review pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
Cooper RA, Hartwig CL, Ferdig MT. Acta Trop. 2005 Jun; 94(3):170-80.
Review Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum.
Trends Parasitol. 2007
Review Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum.
Sanchez CP, Stein WD, Lanzer M. Trends Parasitol. 2007 Jul; 23(7):332-9. Epub 2007 May 10.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.