Medicine

Sulfadoxine and pyrimethamine combination

Indications: This medicine is used to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be travelling to, an area where there is a chance of getting malaria. Sulfadoxine and pyrimethamine combination may also be taken with other medicines for malaria, or may be used for other problems as determined by your doctor.

Directions for use: For treatment of malaria 2 ?3tablets once, depending on body weight.

Pregnancy: Use is not recommended during pregnancy.

Side effects: Fever; increased sensitivity of skin to sunlight; irritation or soreness of tongue; skin rash, abdominal or stomach pain.

Sulfadoxine and pyrimethamine combination Resource:

A non-randomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing the post-treatment circulation of Plasmodium falciparum gametocytes.
Shah NK, Schapira A, Juliano JJ, Srivastava B, Macdonald PD, Poole C, Anvikar A, Meshnick SR, Valecha N, Mishra N.
Antimicrob Agents Chemother. 2013 Apr 15. [Epub ahead of print
Should malaria treatment be guided by a point of care rapid test? A threshold approach to malaria management in rural Burkina Faso.
Bisoffi Z, Tinto H, Sirima BS, Gobbi F, Angheben A, Buonfrate D, Van den Ende J.
PLoS One. 2013;8(3):e58019. doi: 10.1371/journal.pone.0058019. Epub 2013 Mar 5
High prevalence of asymptomatic malaria in a tribal population in eastern India.
Ganguly S, Saha P, Guha SK, Biswas A, Das S, Kundu PK, Maji AK.
J Clin Microbiol. 2013 May;51(5):1439-44. doi: 10.1128/JCM.03437-12. Epub 2013 Feb 20
Bigger babies for women given extra prophylaxis against malaria.
[No authors listed]
BMJ. 2013 Feb 13;346:f907. doi: 10.1136/bmj.f907. No abstract available.
Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis.
Kayentao K, Garner P, van Eijk AM, Naidoo I, Roper C, Mulokozi A, MacArthur JR, Luntamo M, Ashorn P, Doumbo OK, ter Kuile FO.
JAMA. 2013 Feb 13;309(6):594-604. doi: 10.1001/jama.2012.216231. Review
Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India.
Das Sutar SK, Dhangadamajhi G, Kar SK, Ranjit M.
Acta Trop. 2013 Apr;126(1):84-7. doi: 10.1016/j.actatropica.2013.01.010. Epub 2013 Jan 25
Pharmacokinetic profile of artemisinin derivatives and companion drugs used in artemisinin-based combination therapies for the treatment of Plasmodium falciparum malaria in children.
Pawluk SA, Wilby KJ, Ensom MH.
Clin Pharmacokinet. 2013 Mar;52(3):153-67. doi: 10.1007/s40262-012-0026-5
Effect of selected anti-malarial drugs on the blood chemistry and brain serotonin levels in male rabbits.
Eigbibhalu UG, Albert Taiwo EO, Douglass IA, Abimbola EA.
Pak J Pharm Sci. 2013 Jan;26(1):125-9
Analyzing Thiol-Dependent Redox Networks in the Presence of Methylene Blue and Other Antimalarial Agents with RT-PCR-Supported in silico Modeling.
Zirkel J, Cecil A, Schäfer F, Rahlfs S, Ouedraogo A, Xiao K, Sawadogo S, Coulibaly B, Becker K, Dandekar T.
Bioinform Biol Insights. 2012;6:287-302. doi: 10.4137/BBI.S10193. Epub 2012 Dec 3
A community-randomized evaluation of the effect of intermittent preventive treatment in infants on antimalarial drug resistance in southern Tanzania.
Pearce RJ, Ord R, Kaur H, Lupala C, Schellenberg J, Shirima K, Manzi F, Alonso P, Tanner M, Mshinda H, Roper C, Schellenberg D.
J Infect Dis. 2013 Mar 1;207(5):848-59. doi: 10.1093/infdis/jis742. Epub 2012 Dec 5
Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria.
Lin JT, Mbewe B, Taylor SM, Luntamo M, Meshnick SR, Ashorn P.
Trop Med Int Health. 2013 Feb;18(2):175-8. doi: 10.1111/tmi.12028. Epub 2012 Nov 30
Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance.
Mita T, Tanabe K.
Jpn J Infect Dis. 2012;65(6):465-75
Alterations in Plasmodium falciparum genetic structure two years after increased malaria control efforts in western Kenya.
Vardo-Zalik AM, Zhou G, Zhong D, Afrane YA, Githeko AK, Yan G.
Am J Trop Med Hyg. 2013 Jan;88(1):29-36. doi: 10.4269/ajtmh.2012.12-0308. Epub 2012 Nov 19
Pharmacokinetic properties and bioequivalence of two sulfadoxine/pyrimethamine fixed-dose combination tablets: a parallel-design study in healthy Chinese male volunteers.
Liu YM, Zhang KE, Liu Y, Zhang HC, Song YX, Pu HH, Lu C, Liu GY, Jia JY, Zheng QS, Zhu JM, Yu C.
Clin Ther. 2012 Nov;34(11):2212-20. doi: 10.1016/j.clinthera.2012.10.001. Epub 2012 Oct 17
Surveillance of molecular markers of Plasmodium falciparum resistance to sulphadoxine-pyrimethamine 5 years after the change of malaria treatment policy in Ghana.
Duah NO, Quashie NB, Abuaku BK, Sebeny PJ, Kronmann KC, Koram KA.
Am J Trop Med Hyg. 2012 Dec;87(6):996-1003. doi: 10.4269/ajtmh.2012.12-0202. Epub 2012 Oct 8
Insights into the role of heme in the mechanism of action of antimalarials.
Combrinck JM, Mabotha TE, Ncokazi KK, Ambele MA, Taylor D, Smith PJ, Hoppe HC, Egan TJ.
ACS Chem Biol. 2013 Jan 18;8(1):133-7. doi: 10.1021/cb300454t. Epub 2012 Oct 11
Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis.
Pérez del Villar L, Burguillo FJ, López-Abán J, Muro A.
PLoS One. 2012;7(9):e45867. doi: 10.1371/journal.pone.0045867. Epub 2012 Sep 21. Review
In vitro hemolytic effect of sulfadoxine/pyrimethamine and artemether/lumefantrine on malaria parasitized erythrocytes of female patients.
Anaba FC, Ahiante BO, Pepple DJ.
Pak J Pharm Sci. 2012 Oct;25(4):851-5
Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa.
Eisele TP, Larsen DA, Anglewicz PA, Keating J, Yukich J, Bennett A, Hutchinson P, Steketee RW.
Lancet Infect Dis. 2012 Dec;12(12):942-9. doi: 10.1016/S1473-3099(12)70222-0. Epub 2012 Sep 18. Review
Proxies and prevention of malaria in pregnancy.
McGready R, Nosten F.
Lancet Infect Dis. 2012 Dec;12(12):902-3. doi: 10.1016/S1473-3099(12)70240-2. Epub 2012 Sep 18. No abstract available.
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