Medicine

Sulfadoxine and pyrimethamine combination

Indications: This medicine is used to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be travelling to, an area where there is a chance of getting malaria. Sulfadoxine and pyrimethamine combination may also be taken with other medicines for malaria, or may be used for other problems as determined by your doctor.

Directions for use: For treatment of malaria 2 ?3tablets once, depending on body weight.

Pregnancy: Use is not recommended during pregnancy.

Side effects: Fever; increased sensitivity of skin to sunlight; irritation or soreness of tongue; skin rash, abdominal or stomach pain.

Sulfadoxine and pyrimethamine combination Resource:

Comparative efficacy of Artemisinin Combination Therapies (ACTs) in P. falciparum malaria and polymorphism of PfATPase6, Pfcrt, Pfdhfr and Pfdhps genes in tea gardens of Jalpaiguri district, India.
Saha P, Guha SK, Das S, Mullick S, Ganguly S, Biswas A, Bera DK, Chattopadhyay G, Das M, Kundu PK, Ray K, Maji AK.
Antimicrob Agents Chemother. 2012 Feb 6. [Epub ahead of print
Malaria treatment policy change and implementation: the case of Uganda.
Nanyunja M, Nabyonga Orem J, Kato F, Kaggwa M, Katureebe C, Saweka J.
Malar Res Treat. 2011;2011:683167. Epub 2011 Sep 19
Implementation of artemether-lumefantrine treatment policy for malaria at health facilities in Tanzania.
Mugoyela V, Minzi O.
Risk Manag Healthc Policy. 2011;4:89-95. Epub 2011 Sep 6
Defining Plasmodium falciparum Treatment in South West Asia: A Randomized Trial Comparing Artesunate or Primaquine Combined with Chloroquine or SP.
Kolaczinski K, Leslie T, Ali I, Durrani N, Lee S, Barends M, Beshir K, Ord R, Hallett R, Rowland M.
PLoS One. 2012;7(1):e28957. Epub 2012 Jan 31
Efficacy of different primaquine-based antimalarial regimens against Plasmodium falciparum gametocytemia.
Arango EM, Upegui YA, Carmona-Fonseca J.
Acta Trop. 2012 Jan 8. [Epub ahead of print
Progress towards implementation of ACT malaria case-management in public health facilities in the Republic of Sudan: a cluster-sample survey.
Abdelgader TM, Ibrahim AM, Elmardi KA, Githinji S, Zurovac D, Snow RW, Noor AM.
BMC Public Health. 2012 Jan 6;12:11
Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy.
Thomsen TT, Ishengoma DS, Mmbando BP, Lusingu JP, Vestergaard LS, Theander TG, Lemnge MM, Bygbjerg IC, Alifrangis M.
Am J Trop Med Hyg. 2011 Dec;85(6):979-83
Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes.
Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ.
Acta Trop. 2011 Nov 19. [Epub ahead of print
Large differences in prevalence of Pfcrt and Pfmdr1 mutations between Mwanza, Tanzania and Iganga, Uganda-a reflection of differences in policies regarding withdrawal of chloroquine?
Kamugisha E, Bujila I, Lahdo M, Pello-Esso S, Minde M, Kongola G, Naiwumbwe H, Kiwuwa S, Kaddumukasa M, Kironde F, Swedberg G.
Acta Trop. 2012 Feb;121(2):148-51. Epub 2011 Nov 16
The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination.
Malisa AL, Pearce RJ, Mutayoba BM, Abdullah S, Mshinda H, Kachur PS, Bloland P, Roper C.
Malar J. 2011 Oct 26;10:317
Five years of antimalarial resistance marker surveillance in Gaza Province, Mozambique, following artemisinin-based combination therapy roll out.
Raman J, Mauff K, Muianga P, Mussa A, Maharaj R, Barnes KI.
PLoS One. 2011;6(10):e25992. Epub 2011 Oct 14
Molecular assessment of dhfr/dhps mutations among Plasmodium vivax clinical isolates after introduction of sulfadoxine/pyrimethamine in combination with artesunate in Iran.
Afsharpad M, Zakeri S, Pirahmadi S, Djadid ND.
Infect Genet Evol. 2012 Jan;12(1):38-44. Epub 2011 Oct 14
Molecular monitoring of Plasmodium falciparum resistance to antimalarial drugs after adoption of sulfadoxine-pyrimethamine plus artesunate as the first line treatment in Iran.
Afsharpad M, Zakeri S, Pirahmadi S, Djadid ND.
Acta Trop. 2012 Jan;121(1):13-8. Epub 2011 Oct 2
Molecular markers of Plasmodium falciparum drug resistance in southern highland Rwanda.
Zeile I, Gahutu JB, Shyirambere C, Steininger C, Musemakweri A, Sebahungu F, Karema C, Harms G, Eggelte TA, Mockenhaupt FP.
Acta Trop. 2012 Jan;121(1):50-4. Epub 2011 Oct 2
Efficacy of malaria prevention during pregnancy in an area of low and unstable transmission: an individually-randomised placebo-controlled trial using intermittent preventive treatment and insecticide-treated nets in the Kabale Highlands, southwestern Uganda.
Ndyomugyenyi R, Clarke SE, Hutchison CL, Hansen KS, Magnussen P.
Trans R Soc Trop Med Hyg. 2011 Nov;105(11):607-16. Epub 2011 Oct 2
Management of uncomplicated malaria in children under 13 years of age at a district hospital in Senegal: from official guidelines to usual practices.
Sarrassat S, Lalou R, Cissé M, Le Hesran JY.
Malar J. 2011 Sep 29;10:285
Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali.
Tekete MM, Toure S, Fredericks A, Beavogui AH, Sangare CP, Evans A, Smith P, Maiga H, Traore ZI, Doumbo OK, Barnes KI, Djimde AA.
Malar J. 2011 Sep 21;10:275
Change in mutation patterns of Plasmodium vivax dihydrofolate reductase (Pvdhfr) and dihydropteroate synthase (Pvdhps) in P. vivax isolates from malaria endemic areas of Thailand.
Kuesap J, Rungsrihirunrat K, Thongdee P, Ruangweerayut R, Na-Bangchang K.
Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:130-3
Cytogenetic evaluation of Fansidar on human lymphocyte chromosomes in vitro.
Praveen N, Saifi MA, Shadab GG.
J Environ Biol. 2011 Jan;32(1):95-8
Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda.
Baliraine FN, Rosenthal PJ.
J Infect Dis. 2011 Oct 1;204(7):1120-4
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