Medicine

Mefloquine

Indications: This medicine is an antimalarial agent used to treat or prevent malaria caused by Plasmodium falciparum, which is resistant to other antimalarial agents.

Directions for use: Treatment of malaria is initial 750 mg followed by 250 mg given eight hours later. For prevention of malaria the dosage is 250 mg given once a week starting one week before departure and terminating four weeks after leaving malaria- regions.

Pregnancy: may not be used.

Side effects: may include dizziness, nausea, and loss of appetite, stomach pain, diarrhoea, or headache. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience vomiting, rash, ringing in the ears, muscle pain, seizures, confusion, emotional or mood changes, agitation, or hallucinations. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Mefloquine Resource:

Correction to Malaria-Infected Mice Are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine.
Slack RD, Mott BT, Woodard LE, Tripathi A, Sullivan D, Nenortas E, Girdwood SC, Shapiro TA, Posner GH.
J Med Chem. 2012 Feb 2. [Epub ahead of print] No abstract available.
Efficacy of mefloquine treatment and genetic profiles in uncomplicated Plasmodium falciparum malaria in southern Lao PDR.
Toma H, Hatabu T, Vanisaveth V, Mannoor MK, Watanabe H, Li C, Kobayashi J, Phompida S, Kano S, Sato Y.
Southeast Asian J Trop Med Public Health. 2011 Jul;42(4):759-63
Progressive multifocal leukoencephalopathy (PML).
Mizusawa H, Kishida S, Saijo M, Yukishita M, Shishido-Hara Y, Sawa H, Nagashima K, Nukuzuma S, Yamada M.
Rinsho Shinkeigaku. 2011 Nov;51(11):1051-7
Risk Factors for Gametocyte Carriage in Uncomplicated Falciparum Malaria in Children before and after Artemisinin-Based Combination Treatments.
Sowunmi A, Okuboyejo TM, Gbotosho GO, Happi CT.
Chemotherapy. 2012 Jan 19;57(6):497-504. [Epub ahead of print
Akinetic Mutism Caused by HIV-associated Progressive Multifocal Leukoencephalopathy was Successfully Treated with Mefloquine: A Serial Multimodal MRI Study.
Naito K, Ueno H, Sekine M, Kanemitsu M, Ohshita T, Nakamura T, Yamawaki T, Matsumoto M.
Intern Med. 2012;51(2):205-9. Epub 2012 Jan 15
Efficacy of different primaquine-based antimalarial regimens against Plasmodium falciparum gametocytemia.
Arango EM, Upegui YA, Carmona-Fonseca J.
Acta Trop. 2012 Jan 8. [Epub ahead of print
Investigating channel blockers for the treatment of multiple sclerosis: Considerations with mefloquine and carbenoxolone.
Nevin RL.
J Neuroimmunol. 2012 Jan 9. [Epub ahead of print] No abstract available.
Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model.
Souraud JB, Briolant S, Dormoi J, Mosnier J, Savini H, Baret E, Amalvict R, Soulard R, Rogier C, Pradines B.
Malar J. 2012 Jan 10;11(1):13. [Epub ahead of print
Randomized, Prospective, Three-Arm Study to Confirm the Auditory Safety and Efficacy of Artemether-Lumefantrine in Colombian Patients with Uncomplicated Plasmodium falciparum Malaria.
Carrasquilla G, Barón C, Monsell EM, Cousin M, Walter V, Lefèvre G, Sander O, Fisher LM.
Am J Trop Med Hyg. 2012 Jan;86(1):75-83
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after changing drug policy in French Guiana.
Legrand E, Yrinesi J, Ekala MT, Péneau J, Volney B, Berger F, Bouchier C, Bertani S, Musset L, Meynard JB, Mercereau-Puijalon O.
Antimicrob Agents Chemother. 2012 Jan 9. [Epub ahead of print
Extracellular heme enhances the antimalarial activity of artemisinin.
Tangnitipong S, Thaptimthong T, Srihirun S, Unchern S, Kittikool D, Udomsangpetch R, Sibmooh N.
Biol Pharm Bull. 2012;35(1):29-33
Biased measurement of neuropsychiatric adverse effects of pediatric mefloquine treatment.
Nevin RL.
Pediatr Infect Dis J. 2012 Jan;31(1):102. No abstract available.
Efficacy of mefloquine to progressive multifocal leukoencephalopathy initially presented with parkinsonism.
Hirayama M, Nosaki Y, Matsui K, Terao S, Kuwayama M, Tateyama H, Yoshida M, Hashizume Y.
Clin Neurol Neurosurg. 2011 Dec 30. [Epub ahead of print] No abstract available.
Confocal laser scanning microscopic observation on adult Schistosoma japonicum harbored in mice following treatment with single-dose mefloquine.
Xiao SH, Sun J, Xue J.
Parasitol Res. 2011 Dec 27. [Epub ahead of print
Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents.
Tacon C, Guantai EM, Smith PJ, Chibale K.
Bioorg Med Chem. 2012 Jan 15;20(2):893-902. Epub 2011 Dec 3
Histopathological changes of juvenile Schistosoma japonicum harbored in mice treated orally with mefloquine at a smaller single dose.
Zhang CW, Xiao SH.
Parasitol Res. 2011 Dec 22. [Epub ahead of print
High dose artesunate in combination with mefloquine: pharmacovigilance in the Venezuelan Amazon.
Metzger WG, Magris M, Vivas-Martínez S, Giron A, Brooms JD, Villalobos N, Cruz L, Peña Pimentel FN, Perez L, España R.
Trans R Soc Trop Med Hyg. 2011 Dec 7. [Epub ahead of print
Determining the Absolute Configuration of (+)-Mefloquine HCl, the Side-Effect-Reducing Enantiomer of the Antimalaria Drug Lariam.
Schmidt M, Sun H, Rogne P, Scriba GK, Griesinger C, Kuhn LT, Reinscheid UM.
J Am Chem Soc. 2012 Feb 1. [Epub ahead of print
Review: Malaria chemoprophylaxis for travelers to Latin America.
Steinhardt LC, Magill AJ, Arguin PM.
Am J Trop Med Hyg. 2011 Dec;85(6):1015-24. Review
Case report: Peripheral polyneuropathy and mefloquine prophylaxis.
Chester AC, Sandroni P.
Am J Trop Med Hyg. 2011 Dec;85(6):1008-9
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