Medicine

Mefloquine

Indications: This medicine is an antimalarial agent used to treat or prevent malaria caused by Plasmodium falciparum, which is resistant to other antimalarial agents.

Directions for use: Treatment of malaria is initial 750 mg followed by 250 mg given eight hours later. For prevention of malaria the dosage is 250 mg given once a week starting one week before departure and terminating four weeks after leaving malaria- regions.

Pregnancy: may not be used.

Side effects: may include dizziness, nausea, and loss of appetite, stomach pain, diarrhoea, or headache. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience vomiting, rash, ringing in the ears, muscle pain, seizures, confusion, emotional or mood changes, agitation, or hallucinations. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Mefloquine Resource:

Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability.
Castro MM, Rizzi E, Ceron CS, Guimaraes DA, Rodrigues GJ, Bendhack LM, Gerlach RF, Tanus-Santos JE.
Nitric Oxide. 2012 Mar 31;26(3):162-8. doi: 10.1016/j.niox.2012.01.009. Epub 2012 Feb 3
Matrix metalloproteinase inhibition therapy for vascular diseases.
Newby AC.
Vascul Pharmacol. 2012 May;56(5-6):232-44. Epub 2012 Feb 1
Doxycycline in the treatment of bleeding with DMPA: a double-blinded randomized controlled trial.
Abdel-Aleem H, Shaaban OM, Abdel-Aleem MA, Fetih GN.
Contraception. 2012 Feb 9. [Epub ahead of print
Acute transient sensorineural hearing loss due to Anaplasma phagocytophilum.
Ghera P, Kasirye Y, Choudhry MW, Shaw GR, Ejercito VS.
WMJ. 2011 Dec;110(6):288-90
Ffect of periodontal disease and non surgical periodontal treatment on c-reactive protein. Evaluation of type 1 diabetic patients.
Llambés F, Silvestre FJ, Hernández-Mijares A, Guiha R, Bautista D, Caffesse R.
Med Oral Patol Oral Cir Bucal. 2012 Feb 9. [Epub ahead of print
Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo.
Rao RU, Huang Y, Abubucker S, Heinz M, Crosby SD, Mitreva M, Weil GJ.
J Biomed Sci. 2012 Feb 9;19(1):21
Control of the timing and dosage of IGF-I delivery from encapsulated cells.
Patel RS, Chang A, Lysaght MJ, Morgan JR.
J Tissue Eng Regen Med. 2012 Feb 9. doi: 10.1002/term.546. [Epub ahead of print
Detection of Pasteurella multocida isolates from local pigs of India by polymerase chain reaction and their antibiogram.
Rajkhowa S, Shakuntala I, Pegu SR, Das RK, Das A.
Trop Anim Health Prod. 2012 Feb 9. [Epub ahead of print
Activation of proteolytic enzymes and depression of the sarcolemmal Na+/K+-ATPase in ischemia-reperfused heart may be mediated through oxidative stress.
Singh RB, Hryshko L, Freed D, Dhalla NS.
Can J Physiol Pharmacol. 2012 Feb;90(2):249-60. Epub 2012 Feb 8
Selecting allosteric ribozymes.
Piganeau N.
Methods Mol Biol. 2012;848:317-28
Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation.
Garrick MD, Zhao L, Roth JA, Jiang H, Feng J, Foot NJ, Dalton H, Kumar S, Garrick LM.
Biometals. 2012 Feb 7. [Epub ahead of print
Unusual presentations of pediatric neurobrucellosis.
Budnik I, Fuchs I, Shelef I, Krymko H, Greenberg D.
Am J Trop Med Hyg. 2012 Feb;86(2):258-60
A pipeline for the generation of shRNA transgenic mice.
Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW.
Nat Protoc. 2012 Feb 2;7(2):374-93. doi: 10.1038/nprot.2011.446
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, Náray-Fejes-Tóth A, Staub O.
Am J Physiol Renal Physiol. 2012 Apr;302(8):F977-85. Epub 2012 Feb 1
Oesophageal injury suspected to be due to doxycycline ingestion.
Fernandopulle AN, Navarathne NM.
Ceylon Med J. 2011 Dec;56(4):162-3. doi: 10.4038/cmj.v56i4.3897. No abstract available.
A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate.
Rao V, Heard JC, Ghaffari H, Wali A, Mutton LN, Bieberich CJ.
Prostate. 2012 Feb 1. doi: 10.1002/pros.22490. [Epub ahead of print
Comparison of doxycycline-streptomycin, doxycycline-rifampin, and ofloxacin-rifampin in the treatment of brucellosis: a randomized clinical trial.
Hashemi SH, Gachkar L, Keramat F, Mamani M, Hajilooi M, Janbakhsh A, Majzoobi MM, Mahjub H.
Int J Infect Dis. 2012 Apr;16(4):e247-51. Epub 2012 Jan 30
Erratum to: Oral doxycycline for the treatment of chronic leg ulceration.
Sadler GM, Wallace HJ, Stacey MC.
Arch Dermatol Res. 2012 Feb 1. [Epub ahead of print] No abstract available.
Pharmacokinetic interactions of flunixin meglumine and doxycycline in broiler chickens.
Yang F, Li GH, Meng XB, Wang LQ, Huang XH, Shan Q, Zeng DP, Ding HZ, Zeng ZL.
J Vet Pharmacol Ther. 2012 Jan 31. doi: 10.1111/j.1365-2885.2012.01382.x. [Epub ahead of print] No abstract available.
Doxycycline-rifampin versus doxycycline-rifampin-gentamicin in treatment of human brucellosis.
Mile B, Valerija K, Krsto G, Ivan V, Ilir D, Nikola L.
Trop Doct. 2012 Jan;42(1):13-7
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