Medicine

Fluconazole

Indications: This medicine is an azole antifungal used to treat or prevent fungal infections; primary infections caused by Candida albicans and Cryptococcus neoformas.

Directions for use: 50 ?150 mg daily depending of the indication

Pregnancy: Experience is poor. May therefore not be used.

Side effects: include nausea, abdominal pain, or headache. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience vomiting, diarrhoea, or rash. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Fluconazole Resource:

Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
Hull CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL.
Antimicrob Agents Chemother. 2012 May 21. [Epub ahead of print
Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1.
Sasse C, Schillig R, Reimund A, Merk J, Morschhäuser J.
Antimicrob Agents Chemother. 2012 May 21. [Epub ahead of print
Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia.
Gordijn MS, Gemke RJ, van Dalen EC, Rotteveel J, Kaspers GJ.
Cochrane Database Syst Rev. 2012 May 16;5:CD008727
Successful treatment of peritonitis by C. bertholletiae in a chronic kidney failure patient on continuous ambulatory peritoneal dialysis after kidney rejection.
Bhutada K, Borkar SS, Mendiratta DK, Shende VR.
Singapore Med J. 2012 May;53(5):e106-9
Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans.
Vandeputte P, Pradervand S, Ischer F, Coste A, Ferrari S, Harshman K, Sanglard D.
Eukaryot Cell. 2012 May 11. [Epub ahead of print
Impregnation with antimicrobials challenge bonding properties and water sorption behaviour of an acrylic liner.
Salim N, Satterthwaite JD, Rautemaa R, Silikas N.
J Dent. 2012 May 10. [Epub ahead of print
Two hundred and eleven cases of Candida osteomyelitis: 17 case reports and a review of the literature.
Slenker AK, Keith SW, Horn DL.
Diagn Microbiol Infect Dis. 2012 May;73(1):89-93
The changing epidemiology of healthcare-associated candidemia over three decades.
Diekema D, Arbefeville S, Boyken L, Kroeger J, Pfaller M.
Diagn Microbiol Infect Dis. 2012 May;73(1):45-8
Invasive fungal infections following liver transplantation 2003-2007: Incidence, risk factors, survival and the impact of fluconazole-resistant Candida parapsilosis.
Raghuram A, Restrepo A, Safadjou S, Cooley J, Orloff M, Hardy D, Butler S, Koval CE.
Liver Transpl. 2012 May 10. doi: 10.1002/lt.23467. [Epub ahead of print
Rhodotorula Fungemia of an Intensive Care Unit Patient and Review of Published Cases.
Spiliopoulou A, Anastassiou ED, Christofidou M.
Mycopathologia. 2012 May 11. [Epub ahead of print
Identification and Characterization of Antifungal Compounds Using a Saccharomyces cerevisiae Reporter Bioassay.
Tebbets B, Stewart D, Lawry S, Nett J, Nantel A, Andes D, Klein BS.
PLoS One. 2012;7(5):e36021. Epub 2012 May 4
Temporal Trends in Peritonitis Rates, Microbiology and Outcomes: The Major Clinical Complication of Peritoneal Dialysis.
Rocha A, Rodrigues A, Teixeira L, Carvalho MJ, Mendonça D, Cabrita A.
Blood Purif. 2012 May 10;33(4):284-291. [Epub ahead of print
Protothecosis: report of a case with 20-year follow-up, and review of previously published cases.
Todd JR, King JW, Oberle A, Matsumoto T, Odaka Y, Fowler M, Pore RS, Shahan TA, Yin L, Sanusi ID.
Med Mycol. 2012 May 9. [Epub ahead of print
In search of a novel antifungal agent: probing molecular interactions of fluconazole and its analogues with model membranes by NMR and DSC techniques.
Pawar B, Joshi M, Srivastava S, Kanyalkar M.
J Pharm Pharmacol. 2012 Jun;64(6):802-10. doi: 10.1111/j.2042-7158.2012.01489.x. Epub 2012 Mar 12
Mould-active compared with fluconazole prophylaxis to prevent invasive fungal diseases in cancer patients receiving chemotherapy or haematopoietic stem-cell transplantation: a systematic review and meta-analysis of randomised controlled trials.
Ethier MC, Science M, Beyene J, Briel M, Lehrnbecher T, Sung L.
Br J Cancer. 2012 May 8;106(10):1626-37. doi: 10.1038/bjc.2012.147
Localized candidiasis in kidney presented as a mass mimicking renal cell carcinoma.
Song Z, Papanicolaou N, Dean S, Bing Z.
Case Rep Infect Dis. 2012;2012:953590. Epub 2012 Mar 4
Potent synergistic effect of doxycycline with fluconazole against Candida albicans is mediated by interference with iron homeostasis.
Fiori A, Van Dijck P.
Antimicrob Agents Chemother. 2012 May 7. [Epub ahead of print
EUCAST technical note on the EUCAST definitive document EDef 7.2: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST)*
Arendrup MC, Cuenca-Estrella M, Lass-Flörl C, Hope W; the EUCAST-AFST.
Clin Microbiol Infect. 2012 Apr 30. doi: 10.1111/j.1469-0691.2012.03880.x. [Epub ahead of print
The First Korean Case of Candidemia due to Candida dubliniensis.
Yu N, Kim HR, Lee MK.
Ann Lab Med. 2012 May;32(3):225-8. Epub 2012 Apr 18
Simultaneous Quantitation of HIV-Protease Inhibitors Ritonavir, Lopinavir and Indinavir in Human Plasma by UPLC-ESI-MS-MS.
Mishra TD, Kurani H, Singhal P, Shrivastav PS.
J Chromatogr Sci. 2012 May 4. [Epub ahead of print
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