Fluconazole
Indications: This medicine is an azole antifungal used to treat or prevent fungal infections; primary infections caused by Candida albicans and Cryptococcus neoformas.
Directions for use : 50 ?150 mg daily depending of the indication
Pregnancy : Experience is poor. May therefore not be used.
Side effects: include nausea, abdominal pain, or headache. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience vomiting, diarrhoea, or rash. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Fluconazole Resource: Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants. Austin N, McGuire W.Cochrane Database Syst Rev . 2013 Apr 30;4:CD003850. doi: 10.1002/14651858.CD003850.pub4What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection? Ueng SW, Lee CY, Hu CC, Hsieh PH, Chang Y.Clin Orthop Relat Res . 2013 Apr 30. [Epub ahead of printFungal ABC Transporter-Associated Activity of Isoflavonoids from the Root Extract of Dalea formosa. Belofsky G, Kolaczkowski M, Adams E, Schreiber J, Eisenberg V, Coleman CM, Zou Y, Ferreira D.J Nat Prod . 2013 Apr 30. [Epub ahead of printMolecular mechanisms of drug resistance in clinical Candida species isolated in Tunisian Hospitals. Eddouzi J, Parker JE, Vale-Silva LA, Coste A, Ischer F, Kelly S, Manai M, Sanglard D.Antimicrob Agents Chemother . 2013 Apr 29. [Epub ahead of printCandida glabrata Olecranon Bursitis Treated With Bursectomy and Intravenous Caspofungin. Skedros JG, Keenan KE, Trachtenberg JD.J Surg Orthop Adv . 2013 Summer;22(2):179-82Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle. Lee HM, Ok SH, Sung HJ, Eun SY, Kim HJ, Lee SH, Kang S, Shin IW, Lee HK, Chung YK, Choi MJ, Bae SI, Sohn JT.Can J Physiol Pharmacol . 2013 Apr;91(4):285-94. doi: 10.1139/cjpp-2012-0197. Epub 2013 Jan 2Fungal keratitis secondary to Scedosporium apiospermum infection and successful treatment with surgical and medical intervention. Kepez Yildiz B, Hasanreisoglu M, Aktas Z, Aksu G, Kocak BC, Akata F.Int Ophthalmol . 2013 Apr 24. [Epub ahead of printThe role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii. Ferreira GF, Baltazar LD, Santos JR, Monteiro AS, Fraga LA, Resende-Stoianoff MA, Santos DA.J Antimicrob Chemother . 2013 Apr 23. [Epub ahead of printEpidemiological changes with potential implication for antifungal prescription recommendations for fungaemia: data from a nationwide fungaemia surveillance programme. Arendrup MC, Dzajic E, Jensen RH, Johansen HK, Kjaeldgaard P, Knudsen JD, Kristensen L, Leitz C, Lemming LE, Nielsen L, Olesen B, Rosenvinge FS, Røder BL, Schønheyder HC.Clin Microbiol Infect . 2013 Apr 22. doi: 10.1111/1469-0691.12212. [Epub ahead of printThe yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. Simová Z, Poloncová K, Tahotná D, Holič R, Hapala I, Smith AR, White TC, Griač P.Yeast . 2013 Apr 19. doi: 10.1002/yea.2956. [Epub ahead of printChloroquine sensitizes biofilms of Candida albicans to antifungal azoles. Shinde RB, Raut JS, Chauhan NM, Karuppayil SM.Braz J Infect Dis . 2013 Apr 18. doi:pii: S1413-8670(13)00060-3. 10.1016/j.bjid.2012.11.002. [Epub ahead of printSynthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. Cui SF, Ren Y, Zhang SL, Peng XM, Damu GL, Geng RX, Zhou CH.Bioorg Med Chem Lett . 2013 Apr 4. doi:pii: S0960-894X(13)00446-0. 10.1016/j.bmcl.2013.03.118. [Epub ahead of printIncrease in Resistance to Fluconazole and Itraconazole in Trichophyton rubrum Clinical Isolates by Sequential Passages In Vitro under Drug Pressure. Hryncewicz-Gwóźdź A, Kalinowska K, Plomer-Niezgoda E, Bielecki J, Jagielski T.Mycopathologia . 2013 Apr 18. [Epub ahead of printOtomycosis in the north of Iran: common pathogens and resistance to antifungal agents. Nemati S, Hassanzadeh R, Khajeh Jahromi S, Delkhosh Nasrollah Abadi A.Eur Arch Otorhinolaryngol . 2013 Apr 18. [Epub ahead of printHydroxyaldimines as potent in vitro anticryptococcal agents. Magalhães TF, da Silva CM, de Fátima A, da Silva DL, V Modolo L, B Martins CV, Alves RB, Ruiz AL, Longato GB, de Carvalho JE, de Resende-Stoianoff MA.Lett Appl Microbiol . 2013 Apr 18. doi: 10.1111/lam.12086. [Epub ahead of printTrichophyton mentagrophytes cause underestimated contagious zoophilic fungal infection. Czaika VA, Lam PA.Mycoses . 2013 May;56 Suppl 1:33-7. doi: 10.1111/myc.12069Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans. Maurya IK, Thota CK, Verma SD, Sharma J, Rawal MK, Ravikumar B, Sen S, Chauhan NC, Lynn AM, Chauhan VS, Prasad R.J Biol Chem . 2013 Apr 16. [Epub ahead of printEdematous erythema, subcutaneous plaques, and severe pain in the lower extremities in an immunocompromised patient. Ding YG, Fang H.JAMA . 2013 Apr 17;309(15):1632-3. doi: 10.1001/jama.2013.3740. No abstract available.Non-Healing Ulcer Due to Trichosporon loubieri in an Immunocompetent Host and Review of Published Reports. Rastogi V, Rudramurthy SM, Maheshwari M, Nirwan PS, Chakrabarti A, Batra S.Mycopathologia . 2013 Apr 17. [Epub ahead of printPotential drug-drug interactions at a referral hematology-oncology ward in Iran: a cross-sectional study. Hadjibabaie M, Badri S, Ataei S, Moslehi AH, Karimzadeh I, Ghavamzadeh A.Cancer Chemother Pharmacol . 2013 Apr 16. [Epub ahead of printFirst
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