Medicine

Chloroquine

Indications: This medicine is an antimalarial and amebicidal agent used to prevent and treat malaria. It may also be used to treat other conditions as determined by your doctor.

Directions for use: for prevention 125 ?750 mg one a week depending of body weight.

Pregnancy: may be used.

Side effects: include mild headache, nausea, diarrhoea, loss of appetite, stomach cramps, or itching. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience vomiting, sensitivity to light, changes in vision or hearing, ringing in ears, sore throat or fever, personality changes, weakness, or seizures. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Chloroquine Resource:

Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells.
Kim J, Yip ML, Shen X, Li H, Hsin LY, Labarge S, Heinrich EL, Lee W, Lu J, Vaidehi N.
PLoS One. 2012;7(2):e31004. Epub 2012 Feb 3
Synthesis and Antitumoral Evaluation of 7-chloro-4-quinolinylhydrazones Derivatives.
Montenegro RC, Lotufo LV, De Moraes MO, Pessoa Cdo O, Rodrigues FA, Bispo Mde L, Cardoso LN, Kaiser CR, De Souza MV.
Med Chem. 2011 Nov 1;7(6):599-604
pH-Sensitive Capsules as Intracellular Optical Reporters for Monitoring Lysosomal pH Changes Upon Stimulation.
Rivera Gil P, Nazarenus M, Ashraf S, Parak WJ.
Small. 2012 Feb 8. doi: 10.1002/smll.201101780. [Epub ahead of print
Comparative efficacy of Artemisinin Combination Therapies (ACTs) in P. falciparum malaria and polymorphism of PfATPase6, Pfcrt, Pfdhfr and Pfdhps genes in tea gardens of Jalpaiguri district, India.
Saha P, Guha SK, Das S, Mullick S, Ganguly S, Biswas A, Bera DK, Chattopadhyay G, Das M, Kundu PK, Ray K, Maji AK.
Antimicrob Agents Chemother. 2012 Feb 6. [Epub ahead of print
Plasmodium falciparum: Assessment of Selectivity of Action of Chloroquine, Alchornea cordifolia, Ficus polita, and Other Drugs by a Tetrazolium-Based Colorimetric Assay.
Ayisi NK, Appiah-Opong R, Gyan B, Bugyei K, Ekuban F.
Malar Res Treat. 2011;2011:816250. Epub 2011 Dec 1
Malaria treatment policy change and implementation: the case of Uganda.
Nanyunja M, Nabyonga Orem J, Kato F, Kaggwa M, Katureebe C, Saweka J.
Malar Res Treat. 2011;2011:683167. Epub 2011 Sep 19
Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum.
Awasthi G, Satya GB, Das A.
Mem Inst Oswaldo Cruz. 2012 Feb;107(1):129-34
Antiplasmodial and analgesic activities of Clausena anisata.
Okokon JE, Etebong EO, Udobang JA, Essien GE.
Asian Pac J Trop Med. 2012 Mar;5(3):214-9
Defining Plasmodium falciparum Treatment in South West Asia: A Randomized Trial Comparing Artesunate or Primaquine Combined with Chloroquine or SP.
Kolaczinski K, Leslie T, Ali I, Durrani N, Lee S, Barends M, Beshir K, Ord R, Hallett R, Rowland M.
PLoS One. 2012;7(1):e28957. Epub 2012 Jan 31
Different Patterns of pfcrt and pfmdr1 Polymorphisms in P. falciparum Isolates from Nigeria and Brazil: The Potential Role of Antimalarial Drug Selection Pressure.
Gbotosho GO, Folarin OA, Bustamante C, Pereira da Silva LH, Mesquita E, Sowunmi A, Zalis MG, Oduola AM, Happi CT.
Am J Trop Med Hyg. 2012 Feb;86(2):211-3
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells.
Zhou J, Hu SE, Tan SH, Cao R, Chen Y, Xia D, Zhu X, Yang XF, Ong CN, Shen HM.
Autophagy. 2012 Mar 1;8(3). [Epub ahead of print
Improving cognitive outcome in cerebral malaria: insights from clinical and experimental research.
de Mirandaa AS, Brant F, Machado FS, Rachid MA, Teixeira AL.
Cent Nerv Syst Agents Med Chem. 2012 Jan 31. [Epub ahead of print
High prevalence of pfcrt K76t mutants among Plasmodium falciparum isolates from Sabah, Malaysia.
Norahmad NA, Abdullah NR, Yaccob N, Jelip J, Dony JF, Ruslan KF, Sulaiman LH, Sidek HM, Noedl H, Ismail Z.
Southeast Asian J Trop Med Public Health. 2011 Nov;42(6):1322-6
Influenza A/H1N1 vaccination of patients with SLE: can antimalarial drugs restore diminished response under immunosuppressive therapy?
Borba EF, Saad CG, Pasoto SG, Calich AL, Aikawa NE, Ribeiro AC, Moraes JC, Leon EP, Costa LP, Guedes LK, Silva CA, Goncalves CR, Fuller R, Oliveira SA, Ishida MA, Precioso AR, Bonfa E.
Rheumatology (Oxford). 2012 Jan 31. [Epub ahead of print
In vivo sensitivity monitoring of chloroquine for the treatment of uncomplicated vivax malaria in four bordered provinces of Thailand during 2009-2010.
Congpuon K, Satimai W, Sujariyakul A, Intanakom S, Harnpitakpong W, Pranuth Y, Cholpol S, Bualombai P.
J Vector Borne Dis. 2011 Dec;48(4):190-6
Effects of the antimalarial drugs ferroquine and artesunate on Plasmodium yoelii yoelii gametocytegenesis and vectorial transmission.
Mustfa K, Landau I, Chabaud AG, Chavatte JM, Chandenier J, Duong TH, Richard-Lenoble D.
Sante. 2011 Jul-Sep;21(3):133-42
Biodegradable cyclen-based linear and cross-linked polymers as non-viral gene vectors.
Li S, Wang Y, Wang S, Zhang J, Wu SF, Wang BL, Zhu W, Yu XQ.
Bioorg Med Chem. 2012 Feb 15;20(4):1380-7. Epub 2012 Jan 18
The combination of chloroquine and minocycline, a therapeutic option in cerebrospinal infection of Whipple's disease refractory to treatment with ceftriaxone, meropenem and co-trimoxazole.
Feurle GE, Moos V, Schneider T, Fenollar F, Raoult D.
J Antimicrob Chemother. 2012 Jan 27. [Epub ahead of print] No abstract available.
[Ocular and cardiac toxicity by chloroquine].
Gentille Lorente DI.
Rev Med Chil. 2011 Oct;139(10):1384-6. Epub 2012 Jan 3. Spanish. No abstract available.
Ascites due to lupus peritonitis: a rare form of onset of systemic lupus erythematosus.
Pott Júnior H, Amate Neto A, Teixeira MA, Provenza JR.
Rev Bras Reumatol. 2012 Feb;52(1):116-119. English, Portuguese.
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