Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town.
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Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town.
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Authors:
Address: Department of Infectious and Tropical Diseases, Institute of Tropical Diseases, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy, t.stroffolini@policlinicoumberto1.it.
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Publication:
Universal anti-hepatitis B vaccination of infants and of 12-year-old children became mandatory in Italy in 1991. The purpose of this study was to evaluate the persistence of anti-hepatitis B surface (HBs) antibodies several years after a primary course of vaccination.
In 2010, anti-HBs titers were measured in all subjects aged between 5 and 25 years residing in a southern Italian town. Individuals with an anti-hepatitis B antibody concentration of 10 IU/ml or more were considered to be protected.
Of the 671 subjects evaluated, 149 (30%) lacked protective antibodies. Fifty-three (29.4%) of the subjects had been vaccinated ≤10 years earlier and 96 (30.3%) more than 10 years earlier (P = not significant). Subjects vaccinated in infancy were more likely to lack protective anti-HBs antibodies than subjects vaccinated at 12 years of age, regardless of the years elapsed since immunization.
Most subjects maintained protective antibodies for a considerable number of years after vaccination. Vaccination in adolescence results in more proLonged immunogenicity than vaccination in infancy.
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