Long-term efficacy of 10-12 years after being immunized with Chinese hamster ovary cell derived hepatitis B vaccine in Chinese Rural Communities.

Authors:
Address: Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changing District, Beijing 100052, PR China.
Journal:

Publication:

abstract

OBJECTIVE:

To evaluate the Long-term efficacy of Chinese hamster ovary (CHO) cell derived hepatitis B vaccine in country community in China.

METHODS:

A cross-sectional investigation was carried out. Children who were born between 1997 and 1999 and vaccinated with the three doses of CHO-derived hepatitis B vaccine were selected as study objects. Their serum samples were taken to test for hepatitis B virus (HBV) markers, and the results were compared to that before vaccination. In addition, for HBsAg positive children, their mothers were visited.

RESULTS:

1254 Children were enrolled in the study. The prevalence of HBsAg was 0.24% and the vaccine efficacy was 97.0%, similar to that of yeast derived hepatitis vaccines. Among 3 mothers of HBsAg positive children, 2 were HBsAg positive, indicating maternal HBV transmissions.

CONCLUSION:

The long-term efficacy of the CHO-derived hepatitis B vaccine is good and after vaccination maternal transmission is the most important route of spreading HBV.

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