Leptospirosis among hospitalized febrile patients in northern Tanzania.

Authors:
Address: Department of Medicine and Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Journal:

Publication:

abstract

We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed Leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio [OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic.

Related Articles
Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.
Am J Trop Med Hyg. 2012
Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.
Hertz JT, Munishi OM, Ooi EE, Howe S, Lim WY, Chow A, Morrissey AB, Bartlett JA, Onyango JJ, Maro VP, et al. Am J Trop Med Hyg. 2012 Jan; 86(1):171-7.
Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania.
Clin Infect Dis. 2011
Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania.
Prabhu M, Nicholson WL, Roche AJ, Kersh GJ, Fitzpatrick KA, Oliver LD, Massung RF, Morrissey AB, Bartlett JA, Onyango JJ, et al. Clin Infect Dis. 2011 Aug; 53(4):e8-15.
Leptospirosis as a cause of fever in urban Bangladesh.
Am J Trop Med Hyg. 2010
Leptospirosis as a cause of fever in urban Bangladesh.
Kendall EA, LaRocque RC, Bui DM, Galloway R, Ari MD, Goswami D, Breiman RF, Luby S, Brooks WA. Am J Trop Med Hyg. 2010 Jun; 82(6):1127-30.
Retrospective serosurvey of leptospirosis among patients with acute febrile illness and hepatitis in Egypt.
Am J Trop Med Hyg. 2006
Retrospective serosurvey of leptospirosis among patients with acute febrile illness and hepatitis in Egypt.
Ismail TF, Wasfy MO, Abdul-Rahman B, Murray CK, Hospenthal DR, Abdel-Fadeel M, Abdel-Maksoud M, Samir A, Hatem ME, Klena J, et al. Am J Trop Med Hyg. 2006 Dec; 75(6):1085-9.
Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka.
Emerg Infect Dis. 2011
Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka.
Reller ME, Bodinayake C, Nagahawatte A, Devasiri V, Kodikara-Arachichi W, Strouse JJ, Flom JE, Dumler JS, Woods CW. Emerg Infect Dis. 2011 Sep; 17(9):1678-84.
Review Management of adolescents and adults with febrile illness in resource limited areas.
BMJ. 2011
Review Management of adolescents and adults with febrile illness in resource limited areas.
Crump JA, Gove S, Parry CM. BMJ. 2011 Aug 8; 343:d4847. Epub 2011 Aug 8.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.