Isolation and characterization of wild type yellow fever virus in cases temporally associated with 17DD vaccination during an outbreak of yellow fever in Brazil.

Authors: Filippis AM,Nogueira RM,Jabor AV,Schatzmayr HG,Oliveira JC,Dinis SC,Galler R,
Address: Departamento de Virologia, Laboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brazil 4365, 21045-900 Rio de Janeiro, RJ, Brazil. ambispo@ioc.fiocruz.br
Journal: Vaccine.

Publication: 2004 Mar 12;22(9-10):1073-8.

abstract

A mass vaccination was carried out in the state of Minas Gerais, Southeast region of Brazil, to control an outbreak of sylvatic yellow fever in 2001. during the outbreak the surveillance system identified two fatal cases temporally associated with YF vaccination. virus recovered from blood and postmortem samples of both cases was identified as yellow fever virus. Partial nucleotide sequence of parts of prM/E and the non-structural (NS) 5 genes and 3' non-coding region (3' NCR) was employed to characterize the origin of yellow fever virus (YFV) involved in both cases. wild-type YFV was identified as the etiologic agent responsible for the disease.

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