Intracellular events and cell fate in filovirus infection.
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Intracellular events and cell fate in filovirus infection.
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Authors:
Address: Department of Microbiology, School of Medicine, Boston University, Boston, MA 02118, USA. jolejnik@bu.edu
Journal:
Publication:
Free Text: Intracellular events and cell fate in filovirus infection.
Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood and lymph flow. A hallmark of filovirus infection is the depletion of non-infected lymphocytes; however, the molecular mechanisms leading to the observed bystander lymphocyte apoptosis are poorly understood. Also, there is limited knowledge about the fate of infected cells in filovirus disease. In this review we will explore what is known about the Intracellular events leading to virus amplification and cell damage in filovirus infection. Furthermore, we will discuss how cellular dysfunction and cell death may correlate with disease pathogenesis.
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