Infliximab in the treatment of amyloidosis secondary to Crohn's disease.

Authors: Cabezuelo JB,Egea JP,Ramos F,Torrella E,Muray S,Alcázar C,
Address: Hospital General Universitario Reina Sofía, Murcia, Spain. juanbecaro@gmail.com
Journal: Nefrologia.

Publication: 2012 May 14;32(3):385-8. doi: 10.3265/Nefrologia.pre2012.Feb.11332.

abstract

secondary amyloidosis (AA) is a severe complication of progressed Crohn’s disease (CD) for which no effective treatment exists. We present the exceptional case of a 33 year-old male with moderate renal failure and proteinuria, who was simultaneously diagnosed with AA amyloid nephropathy and oligosymptomatic CD. He was treated with Infliximab at 5mg/kg/8 weeks for 4 years, azathioprine at 1-1.5mg/kg/day (first year) and renin-angiotensin-aldosterone system blockers, with no complications. Treatment caused a decrease in proteinuria, improved renal function, and improved inflammatory parameters over time. Inspired by this case, we performed a review of the medical literature and found that infliximab could be a useful tool in the early treatment of amyloidosis secondary to CD.

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