The metacestode stage of Echinococcus multilocularis was cultured in vitro. Sensitivity of protoscoleces to the presence of albendazole sulphoxide, praziquantel and methanol was assessed. 10 micrograms/litre of praziquantel or 500 micrograms/litre of albendazole sulphoxide significantly reduced protoscolex viability. The presence of methanol (at 0.25%) had no significant effect. In vitro culture of E. multilocularis can be used to assess possible chemotherapeutic agents.
Related ArticlesEchinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel.Trans R Soc Trop Med Hyg. 1988
Echinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel.
Taylor DH, Morris DL, Richards KS, Reffin D. Trans R Soc Trop Med Hyg. 1988; 82(4):611-5.
Combination chemotherapy of Echinococcus granulosus--in vitro studies.Trans R Soc Trop Med Hyg. 1988
Combination chemotherapy of Echinococcus granulosus--in vitro studies.
Taylor DH, Morris DL, Richards KS. Trans R Soc Trop Med Hyg. 1988; 82(2):263-4.
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.Gut. 1989
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.
Taylor DH, Morris DL, Reffin D, Richards KS. Gut. 1989 Oct; 30(10):1401-5.
Review [Experimental therapy in Chinese hamsters and rats infected with larval Echinococcus multilocularis by using mebendazole, albendazole and ivermectin with brief review of chemotherapy of human multilocular echinococcosis].Hokkaido Igaku Zasshi. 1987
Review [Experimental therapy in Chinese hamsters and rats infected with larval Echinococcus multilocularis by using mebendazole, albendazole and ivermectin with brief review of chemotherapy of human multilocular echinococcosis].
Inaoka T, Nakao M, Ohnishi K, Kutsumi H. Hokkaido Igaku Zasshi. 1987 Jan; 62(1):54-67.
Review Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?Expert Rev Anti Infect Ther. 2009
Review Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?
Vuitton DA. Expert Rev Anti Infect Ther. 2009 Mar; 7(2):145-9.
Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts.Antimicrob Agents Chemother. 2011
Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts.
Mahanty S, Paredes A, Marzal M, Gonzalez E, Rodriguez S, Dorny P, Guerra-Giraldez C, Garcia HH, Nash T. Antimicrob Agents Chemother. 2011 Jan; 55(1):211-7. Epub 2010 Nov 1.
In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts.Antimicrob Agents Chemother. 2004
In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts.
Palomares F, Palencia G, Pérez R, González-Esquivel D, Castro N, Cook HJ. Antimicrob Agents Chemother. 2004 Jun; 48(6):2302-4.
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.Gut. 1989
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.
Taylor DH, Morris DL, Reffin D, Richards KS. Gut. 1989 Oct; 30(10):1401-5.
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