BACKGROUND and OBJECTIVE:

measles, mumps, rubella and varicella zoster virus (VZV) infections are regarded as typical diseases of childhood: They are normally clinically mild and result in lifelong immunity. Severe clinical disease is known in immunocompromised patients; rubella virus infections during pregnancy often result in congenital rubella syndrome. All these diseases are preventable by vaccination which is recommended in Germany, recently vaccination against VZV for teenager without immunity since July 2001. In the following study we screened for immunity against the four viruses.

PATIENTS AND METHODS:

Serum samples were obtained at the Institute of Medical Virology Frankfurt/Main from January 1999 until December 2000. We tested for specific antibodies against measles (n = 915), against mumps (n = 857), against rubella (n = 1886) and against VZV (n = 2291). Seroprevalences were determined in different age groups.

RESULTS:

Altogether the highest rate of seronegatives is detected in younger children. VZV-seronegativity rates decrease from 74 % to 32 % in younger children. Against rubella also in this age group rate of seronegatives is found in 40 % and less than 10 % by teenagers. From this age group also immunity against rubella is found approximately in 80 % of seropositives.

CONCLUSIONS:

The following study shows that high seronegative rates are detectable, and here specially against VZV-specific antibodies. For seronegative teenagers, vaccination against VZV is now recommended in Germany. Immunization rates of at least 95 % in childhood would be effective in avoiding severe courses of disease and giving protection in pregnancy.

Related Articles
Immunogenicity and reactogenicity of a single dose of live attenuated varicella vaccine and a booster dose of measles-mumps-rubella vaccine given concomitantly at 12 years of age.
Scand J Infect Dis. 2003
Immunogenicity and reactogenicity of a single dose of live attenuated varicella vaccine and a booster dose of measles-mumps-rubella vaccine given concomitantly at 12 years of age.
Parment PA, Svahn A, Rudén U, Bråkenhielm G, Storsaeter J, Akesson L, Linde A. Scand J Infect Dis. 2003; 35(10):736-42.
Antibody persistence for 3 years following two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children.
Eur J Pediatr. 2012
Antibody persistence for 3 years following two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children.
Knuf M, Zepp F, Helm K, Maurer H, Prieler A, Kieninger-Baum D, Douha M, Willems P. Eur J Pediatr. 2012 Mar; 171(3):463-70. Epub 2011 Sep 21.
[Antibodies against vaccine-preventable diseases in pregnant women and their offspring. Measles, mumps, rubella, poliomyelitis, and varicella].
Bundesgesundheitsblatt Gesundheitsforschung...
[Antibodies against vaccine-preventable diseases in pregnant women and their offspring. Measles, mumps, rubella, poliomyelitis, and varicella].
Sauerbrei A, Prager J, Bischoff A, Wutzler P. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2004 Jan; 47(1):10-5.
Review A new combination vaccine for measles, mumps, rubella and varicella.
Drugs Today (Barc). 2006
Review A new combination vaccine for measles, mumps, rubella and varicella.
Zareba G. Drugs Today (Barc). 2006 May; 42(5):321-9.
Review A combination vaccine against measles, mumps, rubella and varicella.
Drugs Today (Barc). 2008
Review A combination vaccine against measles, mumps, rubella and varicella.
Knuf M, Faber J, Barth I, Habermehl P. Drugs Today (Barc). 2008 Apr; 44(4):279-92.
Reliability of medical students' vaccination histories for immunisable diseases.
BMC Public Health. 2008
Reliability of medical students' vaccination histories for immunisable diseases.
Wicker S, Allwinn R, Gottschalk R, Rabenau HF. BMC Public Health. 2008 Apr 15; 8:121. Epub 2008 Apr 15.

To top • Home

---

Show map | Diseases | Vaccination | Chronic disease | Medicine | Pregnancy | Heat & Sunburn | Cold | Security | Useful tips | Faq | News

TraveldoctorOnline 2001 • Disclaimer • webmaster