Authors:
Address: Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, Santiago, Chile. nlopez@interactiva.cl
Journal:

Publication:

abstract

BACKGROUND:

Studies investigating Effects of periodontal treatment (PT) on markers of inflammation in healthy subjects show conflicting results. Few studies have investigated the effects of PT among subjects with coronary heart disease (CHD) risk factors.

AIM:

To report the results of a pilot prospective study on the effects of periodontal treatment on markers of inflammation among subjects with CHD risk factors.

MATERIAL AND METHODS:

Seventy three patients aged 53+/-6 years (25% males) with chronic periodontitis, dyslipidemia and other CHD risk factors were subjected to PT consisting on root planning and oral metronidazol and amoxicillin for 7 days. Periodontal clinical parameters, serum C-reactive protein (CRP), fibrinogen levels and erythrocyte sedimentation rate (ESR) were assessed before and at 6 weeks after PT. Polymorphisms at the ILlA-889 and IL1B+3954 genes were also genotyped.

RESULTS:

After the treatment period, CRP levels significantly increased from 3.6+/-3.7 mg/ L to 5.4+/-5.7 mg/L (p =0.001). No significant changes were observed in fibrinogen levels and ESR. Higher post-treatment CRP levels were significantly associated with the composite polymorphic genotype at the ILlA-889 and IL1B+3954 genes (p =0.0001), and extensive periodontitis (p =0.005). Moderate alcohol consumption appeared as a protective factor for CRP elevation (p =0.029).

CONCLUSIONS:

The increase of the CRP levels after PT in patients with CVD risk factors appeared associated with IL-1 gene polymorphisms and extensive periodontitis.

Related Articles
Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.
J Periodontal Res. 2010
Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.
Nakajima T, Honda T, Domon H, Okui T, Kajita K, Ito H, Takahashi N, Maekawa T, Tabeta K, Yamazaki K. J Periodontal Res. 2010 Feb; 45(1):116-22. Epub 2009 Jul 8.
Evaluation of serum levels of C-reactive protein and lipid profiles in patients with chronic periodontitis and/or coronary heart disease in an ethnic Han population.
Quintessence Int. 2010
Evaluation of serum levels of C-reactive protein and lipid profiles in patients with chronic periodontitis and/or coronary heart disease in an ethnic Han population.
Liu J, Wu Y, Ding Y, Meng S, Ge S, Deng H. Quintessence Int. 2010 Mar; 41(3):239-47.
Non-surgical periodontal therapy lowers serum inflammatory markers: a pilot study.
J Periodontol. 2009
Non-surgical periodontal therapy lowers serum inflammatory markers: a pilot study.
Hussain Bokhari SA, Khan AA, Tatakis DN, Azhar M, Hanif M, Izhar M. J Periodontol. 2009 Oct; 80(10):1574-80.
Review C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.
Ann Intern Med. 2009
Review C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.
Buckley DI, Fu R, Freeman M, Rogers K, Helfand M. Ann Intern Med. 2009 Oct 6; 151(7):483-95.
Review Interleukin-1 composite polymorphism as a risk factor for chronic periodontitis: a review.
SADJ. 2010
Review Interleukin-1 composite polymorphism as a risk factor for chronic periodontitis: a review.
Abu-Saleh T. SADJ. 2010 May; 65(4):160-2, 164-6.

To top • Home

---

Show map | Diseases | Vaccination | Chronic disease | Medicine | Pregnancy | Heat & Sunburn | Cold | Security | Useful tips | Faq | News

TraveldoctorOnline 2001 • Disclaimer • webmaster