The effects of albendazole and praziquantel on the growth of Echinococcus multilocularis were studied in cotton rats. Albendazole (20 and 50 mg/kg) reduced parasite weight and increased the length of survival of infected animals but viable infection was present after treatment. In an in vitro system albendazole sulphoxide entered cysts of E. multilocularis passively. Praziquantel 100 mg/kg was ineffective but 500 mg/kg significantly inhibited growth. A combination of albendazole and praziquantel was no more effective than either agent alone.
Related ArticlesComparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.Gut. 1989
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.
Taylor DH, Morris DL, Reffin D, Richards KS. Gut. 1989 Oct; 30(10):1401-5.
In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide.Trans R Soc Trop Med Hyg. 1988
In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide.
Taylor DH, Morris DL. Trans R Soc Trop Med Hyg. 1988; 82(2):265-7.
Echinococcus multilocularis: ultrastructural effect of in vivo albendazole and praziquantel therapy, singly and in combination.Ann Trop Med Parasitol. 1989
Echinococcus multilocularis: ultrastructural effect of in vivo albendazole and praziquantel therapy, singly and in combination.
Richards KS, Morris DL, Taylor DH. Ann Trop Med Parasitol. 1989 Oct; 83(5):479-84.
Review [Experimental therapy in Chinese hamsters and rats infected with larval Echinococcus multilocularis by using mebendazole, albendazole and ivermectin with brief review of chemotherapy of human multilocular echinococcosis].Hokkaido Igaku Zasshi. 1987
Review [Experimental therapy in Chinese hamsters and rats infected with larval Echinococcus multilocularis by using mebendazole, albendazole and ivermectin with brief review of chemotherapy of human multilocular echinococcosis].
Inaoka T, Nakao M, Ohnishi K, Kutsumi H. Hokkaido Igaku Zasshi. 1987 Jan; 62(1):54-67.
Review Praziquantel: neglected drug? Ineffective treatment? Or therapeutic choice in cystic hydatid disease?Acta Trop. 2009
Review Praziquantel: neglected drug? Ineffective treatment? Or therapeutic choice in cystic hydatid disease?
Bygott JM, Chiodini PL. Acta Trop. 2009 Aug; 111(2):95-101. Epub 2009 Apr 16.
Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts.Antimicrob Agents Chemother. 2011
Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts.
Mahanty S, Paredes A, Marzal M, Gonzalez E, Rodriguez S, Dorny P, Guerra-Giraldez C, Garcia HH, Nash T. Antimicrob Agents Chemother. 2011 Jan; 55(1):211-7. Epub 2010 Nov 1.
Review Diagnosis and treatment of human hydatidosis.Br J Clin Pharmacol. 1993
Review Diagnosis and treatment of human hydatidosis.
Wen H, New RR, Craig PS. Br J Clin Pharmacol. 1993 Jun; 35(6):565-74.
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.Gut. 1989
Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.
Taylor DH, Morris DL, Reffin D, Richards KS. Gut. 1989 Oct; 30(10):1401-5.
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