Yellow Fever

Yellow fever is a viral disease, which is spread by the bite of a mosquito. The geographical distribution of yellow fever is confined to Equatorial Africa and South America. Strangely yellow fever is unknown in Asia despite the presence of mosquitoes capable of spreading the virus.

Nevertheless in general, all travellers going to an endemic area require a yellow fever vaccination certificate and travellers going to some parts of Asia from an endemic region will also require a certificate.Please refr to list of countries.

Manifestation: The disease can have three different presentations:

Subclinical, without any symptoms.

2. Flu-like disease with:

Fever
Muscle pain
Head-ache
Nausea
Vomiting
Recovery

Severe fever with death in a few days with kidney failure, liver failure and haemorrhage.

Diagnose and treatment: No curative treatment is available. Overall about 5% of patients die. Those who recover do so completely and are immune thereafter.

Vaccination: Vaccine against yellow fever is available and effective. This vaccine is recommended before travelling to several countries.

Prevent yellow fever by:

Vaccination
Avoid mosquito bites by remaining in well screened areas
Avoid mosquito bites by remaining in air-conditioned areas.
Use mosquito repellents on skin and clothing
Bring aerosol insecticides to use indoors
Use bednets

Yellow Fever Resource:

The Molecular Dynamics of Trypanosoma brucei UDP-Galactose 4'-Epimerase: A Drug Target for African Sleeping Sickness.

Chem Biol Drug Des

Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases.

Genet Mol Biol

Antitrypanosomal Properties of Panax ginseng C. A. Meyer: New Possibilities for a Remarkable Traditional Drug.

Phytother Res

Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.

Expert Opin Drug Discov

Effect of intermittent hypobaric hypoxia on efficacy & clearance of drugs.

Indian J Med Res

A returning traveller with fever, facial swelling, and skin lesions.

BMJ

Trypanosoma brucei Thymidine Kinase Is Tandem Protein Consisting of Two Homologous Parts, Which Together Enable Efficient Substrate Binding.

J Biol Chem

Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review.

Trop Biomed

Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.

Euro Surveill

Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012.

Euro Surveill

Human African trypanosomiasis in travellers to Kenya.

Euro Surveill

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II.

Curr Med Chem

The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part I.

Curr Med Chem

[Sleeping sickness: end of the epidemic outbreak?].

Rev Neurol (Paris)

Screening and HPLC-Based Activity Profiling for New Antiprotozoal Leads from European Plants.

Sci Pharm

Genetic characterization of Trypanosoma brucei circulating in domestic animals of the Fontem sleeping sickness of Cameroon.

Microbes Infect

(1)H, (15)N, and (13)C chemical shift assignments of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.

Biomol NMR Assign

Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.

Bioorg Med Chem Lett

Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.

J Med Chem

Detection and characterization of Wolbachia infections in laboratory and natural populations of different species of tsetse flies (genus Glossina).

BMC Microbiol

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