Tularaemia
Tularaemia (also known as rabbit fever or deerfly fever) is an infectious disease in ticks and rabbits that is caused by a bacterium (Francisella tularensis). The disease is transmitted by two common ways:
From the bite of an infected tick, deerfly, or mosquito. When broken skin (cuts, abrasions) comes into direct contact with an infected rabbit carcass Although uncommon, people also may contract tularaemia by inhaling contaminated dust or by ingesting contaminated meats or water. Human-to-human transmission of tularaemia is uncommon.
Manifestations: P atients will develop:
Ulcer at the site of infection Swollen lymph nodes Severe fever Patients with the less common form of tularaemia, which occurs mainly after inhalation of bacteria, typically experience:
Sudden chills Fever Weight loss Abdominal pains Tiredness Headaches. Patients with this form of tularaemia may develop an unusual pneumonia that can be fatal.
Diagnose and treatment: Bl ood test demonstrates the diagnose. Treatment with antibiotics is available.
Bite of an infected tick, deerfly, or mosquito Wear protective rubber gloves when handling rodents
Tularemia Resource: Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488. ChemMedChem . 2011 Oct 4;6(10):1832-40. doi: 10.1002/cmdc.201100278. Epub 2011 Aug 10Improving the cost-effectiveness of visual devices for the control of riverine tsetse flies, the major vectors of human African trypanosomiasis . PLoS Negl Trop Dis . 2011 Aug;5(8):e1257. Epub 2011 Aug 2Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by loop-mediated isothermal amplification (LAMP). PLoS Negl Trop Dis . 2011 Aug;5(8):e1249. Epub 2011 Aug 2Prevalence of human African trypanosomiasis in the Democratic Republic of the Congo. PLoS Negl Trop Dis . 2011 Aug;5(8):e1246. Epub 2011 Aug 2How do tsetse recognise their hosts? The role of shape in the responses of tsetse (Glossina fuscipes and G. palpalis) to artificial hosts. PLoS Negl Trop Dis . 2011 Aug;5(8):e1226. Epub 2011 Aug 2Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei. Biochem Biophys Res Commun . 2011 Aug 26;412(2):286-90. Epub 2011 Jul 28Improved PCR-RFLP for the detection of diminazene resistance in Trypanosoma congolense under field conditions using filter papers for sample storage. PLoS Negl Trop Dis . 2011 Jul;5(7):e1223. Epub 2011 Jul 26. No abstract available.Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps. Enzyme Res . 2011;2011:543912. Epub 2011 Jul 26IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-κB p50 member in Trypanosoma congolense infection-resistant C57BL/6 mice. Eur J Immunol . 2011 Nov;41(11):3270-80. doi: 10.1002/eji.201041307. Epub 2011 Sep 19Epidemiological aspects of the transmission of the parasites causing human African trypanosomiasis in Angola. Ann Trop Med Parasitol . 2011 Apr;105(3):261-5. No abstract available.Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense. BMC Biochem . 2011 Jul 30;12:39Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine. Parasitol Res . 2012 Feb;110(2):521-6. Epub 2011 Jul 26The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats. Asian Pac J Trop Med . 2011 May;4(5):337-41. Epub 2011 Jun 22The characterization of a unique Trypanosoma brucei β-hydroxybutyrate dehydrogenase. Mol Biochem Parasitol . 2011 Oct;179(2):100-6. Epub 2011 Jul 7Population genetics of Glossina palpalis palpalis from central African sleeping sickness foci. Parasit Vectors . 2011 Jul 18;4:140HIV-1 replication in monocyte-derived dendritic cells is stimulated by melarsoprol, one of the main drugs against human African trypanosomiasis . J Mol Biol . 2011 Jul 29;410(5):1052-64Specializations in a successful parasite: what makes the bloodstream-form African trypanosome so deadly? Mol Biochem Parasitol . 2011 Oct;179(2):51-8. Epub 2011 Jul 7. ReviewMono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma. Arzneimittelforschung . 2011;61(5):317-25Synchronization of pathogenic protozoans. Methods Mol Biol . 2011;761:201-10Trypanosome prereplication machinery: a potential new target for an old problem. Enzyme Res . 2011;2011:518258. Epub 2011 May 25First
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