Leptospirosis

Leptospirosis is a bacterial disease. Bacteria of the genus Leptospira ictero-haemorrhagica cause it. Humans become infected through contact with water, food, or soil containing urine from these infected animals. This may happen by swallowing contaminated food or water or through skin contact, especially with mucosal surfaces, such as the eyes or nose, or with broken skin.

Manifestations: In humans it causes a wide range of symptoms, and some infected persons may have no symptoms at all. Symptoms of leptospirosis include:

• High fever
• Severe headache
• Chills
• Muscle aches
• Vomiting
• Jaundice (yellow skin and eyes)
• Red eyes
• Abdominal pain
• Diarrhoea
• Rash.

If the disease is not treated, the patient could develop:

• Kidney damage
• Meningitis (inflammation of the membrane around the brain and spinal cord)
• Liver failure
• Respiratory distress
• In rare cases death

Diagnose and treatment: Leptospirosis is confirmed by laboratory testing of a blood or urine sample. Treatment is available and effective.

Prevent Leptospirosis by:

• Do not swimming or wading in water that might be contaminated with animal urine.
• Protective clothing or footwear should be worn by those exposed to contaminated water or soil.

Leptospiros Resource:

Rapid diagnosis of leptospirosis by multiplex PCR.
Ahmed SA, Sandai DA, Musa S, Hoe CH, Riadzi M, Lau KL, Tang TH.
Malays J Med Sci. 2012 Jul;19(3):9-16
Leptospira spp. In Commensal Rodents, Beijing, China.
Wang C, He H.
J Wildl Dis. 2013 Apr;49(2):461-3. doi: 10.7589/2012-10-261
Source tracking of human leptospirosis: serotyping and genotyping of Leptospira isolated from rodents in the epidemic area of Guizhou province, China.
Li S, Wang D, Zhang C, Wei X, Tian K, Li X, Nie Y, Liu Y, Yao G, Zhou J, Tang G, Jiang X, Yan J.
BMC Microbiol. 2013 Apr 1;13:75. doi: 10.1186/1471-2180-13-75
Epidemiological study of animal leptospirosis in new caledonia.
Roqueplo C, Cabre O, Davoust B, Kodjo A.
Vet Med Int. 2013;2013:826834. doi: 10.1155/2013/826834. Epub 2013 Feb 28
Serovar diversity of pathogenic Leptospira circulating in the French West Indies.
Bourhy P, Herrmann Storck C, Theodose R, Olive C, Nicolas M, Hochedez P, Lamaury I, Zinini F, Brémont S, Landier A, Cassadou S, Rosine J, Picardeau M.
PLoS Negl Trop Dis. 2013 Mar;7(3):e2114. doi: 10.1371/journal.pntd.0002114. Epub 2013 Mar 14
Interaction of Leptospira interrogans with Human Proteolytic Systems Enhances Dissemination through Endothelial Cells and Protease Levels.
Vieira ML, Alvarez-Flores MP, Kirchgatter K, Romero EC, Alves IJ, de Morais ZM, Vasconcellos SA, Chudzinski-Tavassi AM, Nascimento AL.
Infect Immun. 2013 May;81(5):1764-74. doi: 10.1128/IAI.00020-13. Epub 2013 Mar 11
Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea.
Monte LG, Jorge S, Xavier MA, Leal FM, Amaral MG, Seixas FK, Dellagostin OA, Hartleben CP.
Acta Trop. 2013 May;126(2):164-6. doi: 10.1016/j.actatropica.2013.02.009. Epub 2013 Feb 19
Asymptomatic and chronic carriage of Leptospira interrogans serovar Pomona in California sea lions (Zalophus californianus).
Prager KC, Greig DJ, Alt DP, Galloway RL, Hornsby RL, Palmer LJ, Soper J, Wu Q, Zuerner RL, Gulland FM, Lloyd-Smith JO.
Vet Microbiol. 2013 May 31;164(1-2):177-83. doi: 10.1016/j.vetmic.2013.01.032. Epub 2013 Feb 4
Molecular typing of Leptospira spp. strains isolated from field mice confirms a link to human leptospirosis.
Li SJ, Wang DM, Zhang CC, Li XW, Yang HM, Tian KC, Wei XY, Liu Y, Tang GP, Jiang XG, Yan J.
Epidemiol Infect. 2013 Feb 13:1-8. [Epub ahead of print
Diagnosis and epidemiology of leptospirosis.
Picardeau M.
Med Mal Infect. 2013 Jan;43(1):1-9. doi: 10.1016/j.medmal.2012.11.005. Epub 2013 Jan 18
Leptospirosis in South Africa.
Saif A, Frean J, Rossouw J, Trataris AN.
Onderstepoort J Vet Res. 2012 Jun 20;79(2):E1. doi: 10.4102/ojvr.v79i2.478
Risk factors and predictors of severe leptospirosis in New Caledonia.
Tubiana S, Mikulski M, Becam J, Lacassin F, Lefèvre P, Gourinat AC, Goarant C, D'Ortenzio E.
PLoS Negl Trop Dis. 2013 Jan;7(1):e1991. doi: 10.1371/journal.pntd.0001991. Epub 2013 Jan 10
LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: presentation of new data and reevaluation of previous studies.
Pinne M, Haake DA.
PLoS One. 2013;8(1):e51025. doi: 10.1371/journal.pone.0051025. Epub 2013 Jan 8
Adhesin activity of Leptospira interrogans lipoprotein identified by in vivo and in vitro shotgun phage display.
Lima SS, Ching AT, Fávaro RD, Da Silva JB, Oliveira ML, Carvalho E, Abreu PA, Vasconcellos SA, Ho PL.
Biochem Biophys Res Commun. 2013 Feb 8;431(2):342-7. doi: 10.1016/j.bbrc.2012.12.095. Epub 2013 Jan 3
Our experience using real-time PCR for the detection of the gene that encodes the superficial lipoprotein LipL32 of the pathogenic leptospires to confirm the acute form of human leptospirosis.
Kucerova P, Cermakova Z, Pliskova L, Pavlis O, Kubickova P, Kleprlikova H, Valenta Z.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Dec 7. doi: 10.5507/bp.2012.109. [Epub ahead of print
Characterization of the Bat proteins in the oxidative stress response of Leptospira biflexa.
Stewart PE, Carroll JA, Dorward DW, Stone HH, Sarkar A, Picardeau M, Rosa PA.
BMC Microbiol. 2012 Dec 13;12:290. doi: 10.1186/1471-2180-12-290
The inhibition effect of antiserum on the motility of Leptospira.
Guo Y, Nakamura S, Ando T, Yoneyama H, Kudo S, Isogai E.
Curr Microbiol. 2013 Apr;66(4):359-64. doi: 10.1007/s00284-012-0281-6. Epub 2012 Dec 9
Influence of risk factors on renal leptospiral load in naturally infected wild black rats.
Desvars A, Michault A, Chiroleu F.
Acta Trop. 2013 Mar;125(3):258-61. doi: 10.1016/j.actatropica.2012.11.011. Epub 2012 Dec 7
The lipoprotein LipL32, an enigma of leptospiral biology.
Murray GL.
Vet Microbiol. 2013 Mar 23;162(2-4):305-14. doi: 10.1016/j.vetmic.2012.11.005. Epub 2012 Nov 9
Identification of epitopes in Leptospira borgpetersenii leucine-rich repeat proteins.
Nitipan S, Sritrakul T, Kunjantarachot A, Prapong S.
Infect Genet Evol. 2013 Mar;14:46-57. doi: 10.1016/j.meegid.2012.10.014. Epub 2012 Nov 28
First 1 2 3 4 5 6 7 8 9 Next Last 51/1006 Jump: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51