Lassa fever is an acute viral illness that occurs in West Africa. The virus, a member of the virus family Arenaviridae, and is zoonotic, or animal-borne. Rodents shed the virus in urine and droppings. Therefore, the virus can be transmitted through direct contact with these materials, through touching objects or eating food contaminated with these materials, or through cuts or sores.
Manifestation: Symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. These include: Fever Pain behind the chest wall Sore throat Back pain Cough Abdominal pain Vomiting Diarrhoea Rash
After four weeks occur: Bleeding Ascites Shock Death in 50 % of the patients
Diagnose and treatment: Virus is demonstrated in blood and urine. Specific treatment is not available.
Prevent Lassa fever by. Avoid contact with rodents.
Lassa Fever Resource: Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression. Jiang X, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. J Biol Chem. 2013 Apr 24. [Epub ahead of print Lassa fever presenting as acute abdomen: a case series. Dongo AE, Kesieme EB, Iyamu CE, Okokhere PO, Akhuemokhan OC, Akpede GO. Virol J. 2013 Apr 19;10:123. doi: 10.1186/1743-422X-10-123 Vaccination Strategies against Highly Pathogenic Arenaviruses: The Next Steps toward Clinical Trials. Olschläger S, Flatz L. PLoS Pathog. 2013 Apr;9(4):e1003212. doi: 10.1371/journal.ppat.1003212. Epub 2013 Apr 11 A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents. Madrid PB, Chopra S, Manger ID, Gilfillan L, Keepers TR, Shurtleff AC, Green CE, Iyer LV, Dilks HH, Davey RA, Kolokoltsov AA, Carrion R Jr, Patterson JL, Bavari S, Panchal RG, Warren TK, Wells JB, Moos WH, Burke RL, Tanga MJ. PLoS One. 2013;8(4):e60579. doi: 10.1371/journal.pone.0060579. Epub 2013 Apr 5 TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine. Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, Dekruyff RH, Choe H. PLoS Pathog. 2013 Mar;9(3):e1003232. doi: 10.1371/journal.ppat.1003232. Epub 2013 Mar 28 Identification of virulence determinants within the L genomic segment of the Pichinde arenavirus. McLay L, Lan S, Ansari A, Liang Y, Ly H. J Virol. 2013 Apr 3. [Epub ahead of print Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR. Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21 Lassa fever in West Africa: evidence for an expanded region of endemicity. Sogoba N, Feldmann H, Safronetz D. Zoonoses Public Health. 2012 Sep;59 Suppl 2:43-7. doi: 10.1111/j.1863-2378.2012.01469.x Vaccine Platforms to Control Arenaviral Hemorrhagic Fevers. Carrion R Jr, Bredenbeek P, Jiang X, Tretyakova I, Pushko P, Lukashevich IS. J Vaccines Vaccin. 2012 Nov 20;3(7). doi:pii: 1000160 An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity. Zapata JC, Poonia B, Bryant J, Davis H, Ateh E, George L, Crasta O, Zhang Y, Slezak T, Jaing C, Pauza CD, Goicochea M, Moshkoff D, Lukashevich IS, Salvato MS. Virol J. 2013 Feb 12;10:52. doi: 10.1186/1743-422X-10-52 A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection. Bond N, Schieffelin JS, Moses LM, Bennett AJ, Bausch DG. Am J Trop Med Hyg. 2013 Feb;88(2):241-4. doi: 10.4269/ajtmh.2012.12-0466 [Highly contagious diseases with human-to-human transmission]. Rybka A, Szanyi J, Kapla J, Plíšek S. Klin Mikrobiol Infekc Lek. 2012 Dec;18(6):180-3. Czech. Viral haemorrhagic fevers in healthcare settings. Ftika L, Maltezou HC. J Hosp Infect. 2013 Mar;83(3):185-92. doi: 10.1016/j.jhin.2012.10.013. Epub 2013 Jan 16 A recently isolated Lassa virus from Mali demonstrates atypical clinical disease manifestations and decreased virulence in cynomolgus macaques. Safronetz D, Strong JE, Feldmann F, Haddock E, Sogoba N, Brining D, Geisbert TW, Scott DP, Feldmann H. J Infect Dis. 2013 Apr 15;207(8):1316-27. doi: 10.1093/infdis/jit004. Epub 2013 Jan 9 Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone. Kelly JD, Barrie MB, Ross RA, Temple BA, Moses LM, Bausch DG. BMC Int Health Hum Rights. 2013 Jan 2;13:2. doi: 10.1186/1472-698X-13-2 Seroepidemiological study reveals regional co-occurrence of Lassa- and Hantavirus antibodies in Upper Guinea, West Africa. Klempa B, Koulemou K, Auste B, Emmerich P, Thomé-Bolduan C, Günther S, Koivogui L, Krüger DH, Fichet-Calvet E. Trop Med Int Health. 2013 Mar;18(3):366-71. doi: 10.1111/tmi.12045. Epub 2012 Dec 31 Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan. Moraz ML, Pythoud C, Turk R, Rothenberger S, Pasquato A, Campbell KP, Kunz S. Cell Microbiol. 2013 May;15(5):689-700. doi: 10.1111/cmi.12078. Epub 2012 Dec 20 A Historical Look at the First Reported Cases of Lassa Fever: IgG Antibodies 40 Years After Acute Infection. Bond N, Schieffelin JS, Moses LM, Bennett AJ, Bausch DG. Am J Trop Med Hyg. 2012 Dec 31. [Epub ahead of print Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever. McLay L, Ansari A, Liang Y, Ly H. Antiviral Res. 2013 Feb;97(2):81-92. doi: 10.1016/j.antiviral.2012.12.003. Epub 2012 Dec 20 The search for animal models for Lassa fever vaccine development. Lukashevich IS. Expert Rev Vaccines. 2013 Jan;12(1):71-86. doi: 10.1586/erv.12.139 First
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