Lassa Fever

Lassa fever is an acute viral illness that occurs in West Africa. The virus, a member of the virus family Arenaviridae, and is zoonotic, or animal-borne. Rodents shed the virus in urine and droppings. Therefore, the virus can be transmitted through direct contact with these materials, through touching objects or eating food contaminated with these materials, or through cuts or sores.

Manifestation: Symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. These include:

Fever
Pain behind the chest wall
Sore throat
Back pain
Cough
Abdominal pain
Vomiting
Diarrhoea
Rash

After four weeks occur:

Bleeding
Ascites
Shock
Death in 50 % of the patients

Diagnose and treatment: Virus is demonstrated in blood and urine. Specific treatment is not available.

Prevent Lassa fever by.

Avoid contact with rodents.

Lassa Fever Resource:

Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression.

J Biol Chem

Lassa fever presenting as acute abdomen: a case series.

Virol J

Vaccination Strategies against Highly Pathogenic Arenaviruses: The Next Steps toward Clinical Trials.

PLoS Pathog

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents.

PLoS One

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine.

PLoS Pathog

Identification of virulence determinants within the L genomic segment of the Pichinde arenavirus.

J Virol

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

Science

Lassa fever in West Africa: evidence for an expanded region of endemicity.

Zoonoses Public Health

Vaccine Platforms to Control Arenaviral Hemorrhagic Fevers.

J Vaccines Vaccin

An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity.

Virol J

A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection.

Am J Trop Med Hyg

[Highly contagious diseases with human-to-human transmission].

Klin Mikrobiol Infekc Lek

Viral haemorrhagic fevers in healthcare settings.

J Hosp Infect

A recently isolated Lassa virus from Mali demonstrates atypical clinical disease manifestations and decreased virulence in cynomolgus macaques.

J Infect Dis

Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone.

BMC Int Health Hum Rights

Seroepidemiological study reveals regional co-occurrence of Lassa- and Hantavirus antibodies in Upper Guinea, West Africa.

Trop Med Int Health

Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan.

Cell Microbiol

A Historical Look at the First Reported Cases of Lassa Fever: IgG Antibodies 40 Years After Acute Infection.

Am J Trop Med Hyg

Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever.

Antiviral Res

The search for animal models for Lassa fever vaccine development.

Expert Rev Vaccines

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