Kyasanur Forest Disease
Kyasanur forest disease was first recognised in 1957 during a fatal epizootic of wild monkeys in Mysore (Karnataka), India. Forest workers are particularly at risk, and mortality may reach 10%. The causative virus is a tick-borne virus belonging to the genus Flavivirus of the family Flaviviridae, which has been isolated from ticks, monkeys, and humans. The principal vector appears to be the tick Haemaphysalis spinigera, whereas the vertebrate reservoir is uncertain.
Manifestations: The symptoms are:
Bleeding from the nose and throat
Mortality may reach 10 percent.
Diagnose and treatment: There is no specific treatment for the disease.
Vaccination: The vaccine available for control of Kyasanur forest disease is an inactivated virus vaccine.
Prevent Kyasanur forest disease by: Vaccination Avoid mosquito bites by remaining in well screened areas Avoid mosquito bites by remaining in air-conditioned areas. Use mosquito repellents on skin and clothing Bring aerosol insecticides to use indoors Use bednets.
KyasanurForest Disease Resource: Coverage and effectiveness of Kyasanur forest disease (KFD) vaccine in Karnataka, South India, 2005-10. Kasabi GS, Murhekar MV, Sandhya VK, Raghunandan R, Kiran SK, Channabasappa GH, Mehendale SM. PLoS Negl Trop Dis. 2013 Jan;7(1):e2025. doi: 10.1371/journal.pntd.0002025. Epub 2013 Jan 24 Kyasanur Forest disease, India, 2011-2012. Kasabi GS, Murhekar MV, Yadav PD, Raghunandan R, Kiran SK, Sandhya VK, Channabasappa GH, Mishra AC, Mourya DT, Mehendale SM. Emerg Infect Dis. 2013 Feb;19(2):278-81. doi: 10.3201/eid1902.120544 Kyasanur forest disease. Holbrook MR. Antiviral Res. 2012 Dec;96(3):353-62. doi: 10.1016/j.antiviral.2012.10.005. Epub 2012 Oct 27 Diagnosis of Kyasanur forest disease by nested RT-PCR, real-time RT-PCR and IgM capture ELISA. Mourya DT, Yadav PD, Mehla R, Barde PV, Yergolkar PN, Kumar SR, Thakare JP, Mishra AC. J Virol Methods. 2012 Dec;186(1-2):49-54. doi: 10.1016/j.jviromet.2012.07.019. Epub 2012 Jul 31 Seroprevalence of Alkhurma and other hemorrhagic fever viruses, Saudi Arabia. Memish ZA, Albarrak A, Almazroa MA, Al-Omar I, Alhakeem R, Assiri A, Fagbo S, MacNeil A, Rollin PE, Abdullah N, Stephens G. Emerg Infect Dis. 2011 Dec;17(12):2316-8. doi: 10.3201/eid1712.110658 The generation of a reverse genetics system for Kyasanur Forest Disease Virus and the ability to antagonize the induction of the antiviral state in vitro. Cook BW, Cutts TA, Court DA, Theriault S. Virus Res. 2012 Feb;163(2):431-8. doi: 10.1016/j.virusres.2011.11.002. Epub 2011 Nov 12 Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts. Dodd KA, Bird BH, Khristova ML, Albariño CG, Carroll SA, Comer JA, Erickson BR, Rollin PE, Nichol ST. PLoS Negl Trop Dis. 2011 Oct;5(10):e1352. doi: 10.1371/journal.pntd.0001352. Epub 2011 Oct 4 Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. Charrel RN, Gould EA. Emerg Infect Dis. 2011 Aug;17(8):1573-4; author reply 1574. doi: 10.3201/eid1708.101858. No abstract available. Kyasanur Forest Disease virus Alkhurma subtype in ticks, Najran Province, Saudi Arabia. Mahdi M, Erickson BR, Comer JA, Nichol ST, Rollin PE, AlMazroa MA, Memish ZA. Emerg Infect Dis. 2011 May;17(5):945-7. doi: 10.3201/eid1705.101824. No abstract available. Computer-based comparison of structural features of envelope protein of Alkhurma hemorrhagic fever virus with the homologous proteins of two closest viruses. Mohabatkar H. Protein Pept Lett. 2011 Jun;18(6):559-67 Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010. Carletti F, Castilletti C, Di Caro A, Capobianchi MR, Nisii C, Suter F, Rizzi M, Tebaldi A, Goglio A, Passerini Tosi C, Ippolito G. Emerg Infect Dis. 2010 Dec;16(12):1979-82. doi: 10.3201/eid1612.101092 Tick-borne flaviviruses. Lasala PR, Holbrook M. Clin Lab Med. 2010 Mar;30(1):221-35. doi: 10.1016/j.cll.2010.01.002. Review Recent ancestry of Kyasanur Forest disease virus. Mehla R, Kumar SR, Yadav P, Barde PV, Yergolkar PN, Erickson BR, Carroll SA, Mishra AC, Nichol ST, Mourya DT. Emerg Infect Dis. 2009 Sep;15(9):1431-7. doi: 10.3201/eid1509.080759 Zoonotic tick-borne flaviviruses. Dobler G. Vet Microbiol. 2010 Jan 27;140(3-4):221-8. doi: 10.1016/j.vetmic.2009.08.024. Epub 2009 Aug 26. Review The zoonotic flaviviruses of southern, south-eastern and eastern Asia, and Australasia: the potential for emergent viruses. Mackenzie JS, Williams DT. Zoonoses Public Health. 2009 Aug;56(6-7):338-56. doi: 10.1111/j.1863-2378.2008.01208.x. Review Isolation of kyasanur forest disease virus from febrile patient, yunnan, china. Wang J, Zhang H, Fu S, Wang H, Ni D, Nasci R, Tang Q, Liang G. Emerg Infect Dis. 2009 Feb;15(2):326-8 Pathogenic flaviviruses. Gould EA, Solomon T. Lancet. 2008 Feb 9;371(9611):500-9. doi: 10.1016/S0140-6736(08)60238-X. Review Upcoming and future strategies of tick control: a review. Ghosh S, Azhahianambi P, Yadav MP. J Vector Borne Dis. 2007 Jun;44(2):79-89. Review Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Grard G, Moureau G, Charrel RN, Lemasson JJ, Gonzalez JP, Gallian P, Gritsun TS, Holmes EC, Gould EA, de Lamballerie X. Virology. 2007 Apr 25;361(1):80-92. Epub 2006 Dec 13 Kyasanur forest disease: an epidemiological view in India. Pattnaik P. Rev Med Virol. 2006 May-Jun;16(3):151-65. Review. Erratum in: Rev Med Virol. 2008 May-Jun;18(3):211. First
To top Back to list of diseases Home Show map | Diseases | Vaccination | Chronic disease | Medicine | Pregnancy | Heat & Sunburn | Cold | Security | Useful tips | News | TraveldoctorOnline 2001 Disclaimer webmaster The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.