Hepatitis E

Hepatitis E virus (HEV), the major etiologic agent of enterically transmitted non-A, non-B hepatitis worldwide.

Manifestation: The incubation period following exposure to HEV ranges from 15 to 60 days (mean, 40 days). Typical clinical signs and symptoms of acute hepatitis E are similar to those of other types of viral hepatitis and include:

• Abdominal pain
• Anorexia
• Dark urine
• Fever
• Hepatomegaly
• Jaundice
• Malaise
• Nausea
• Vomiting.
• Other less common symptoms include arthralgia, diarrhoea, pruritus, and urticarial rash. The period of infectivity following acute infection has not been determined but virus excretion in stools has been demonstrated up to 14 days after illness onset.

No evidence of chronic infection has been detected in long-term follow-up of patients with hepatitis E

Diagnose and treatment: Blood test demonstrates the infection. Therapy is not available, but there recovery is spontaneously. Vaccine is not available.

Prevent hepatitis E by:

• Avoid drinking contaminated water
• Avoid eating contaminated food.

Hepatitis E Resource:

Hepatitis e virus infection: more common than previously realized?
Sherman KE.
Gastroenterol Hepatol (N Y). 2011 Nov;7(11):759-61. No abstract available.
Hepatitis E Virus and the Kidney in Solid-Organ Transplant Patients.
Kamar N, Weclawiak H, Guilbeau-Frugier C, Legrand-Abravanel F, Cointault O, Ribes D, Esposito L, Cardeau-Desangles I, Guitard J, Sallusto F, Muscari F, Peron JM, Alric L, Izopet J, Rostaing L.
Transplantation. 2012 Jan 31. [Epub ahead of print
Prevalence of antibodies and RNA genome of hepatitis E virus in a cohort of French immunocompromised.
Maylin S, Stephan R, Molina JM, Peraldi MN, Scieux C, Nicand E, Simon F, Delaugerre C.
J Clin Virol. 2012 Jan 29. [Epub ahead of print
Guillain-Barré syndrome associated with acute hepatitis E infection.
Tse AC, Cheung RT, Ho SL, Chan KH.
J Clin Neurosci. 2012 Jan 26. [Epub ahead of print
Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E.
Teo CG.
Epidemiol Infect. 2012 Jan 25:1-21. [Epub ahead of print
Seroprevalence of hepatitis E antibodies and risk profile of HEV seropositivity in The Netherlands, 2006-2007.
Verhoef L, Koopmans M, Duizer E, Bakker J, Reimerink J, VAN Pelt W.
Epidemiol Infect. 2012 Jan 24:1-10. [Epub ahead of print
Systematic screening for novel, serologically reactive Hepatitis E Virus epitopes.
Osterman A, Vizoso Pinto MG, Haase R, Nitschko H, Jaeger S, Sander M, Motz M, Mohn U, Baiker A.
Virol J. 2012 Jan 23;9(1):28. [Epub ahead of print
Epidemiological and virological characteristics of symptomatic acute hepatitis E in Greater Cairo, Egypt.
Delarocque-Astagneau E, Abravanel F, Moshen A, Le Fouler L, Gad RR, El-Daly M, Ibrahim EM, El-Aidy S, Lashin T, El-Hoseiny M, Izopet J, Mohamed MK, Fontanet A, Abdel Hamid M.
Clin Microbiol Infect. 2011 Nov 16. doi: 10.1111/j.1469-0691.2011.03727.x. [Epub ahead of print
HIV, HEV and cirrhosis: evidence of a possible link from eastern Spain.
Jardi R, Crespo M, Homs M, Van den Eyden E, Girones R, Rodriguez-Manzano J, Caballero A, Buti M, Esteban R, Rodriguez-Frias F.
HIV Med. 2012 Jan 18. doi: 10.1111/j.1468-1293.2011.00985.x. [Epub ahead of print
Immunohistochemistry for the diagnosis of hepatitis E virus infection.
Gupta P, Jagya N, Pabhu SB, Durgapal H, Acharya SK, Panda SK.
J Viral Hepat. 2012 Feb;19(2):e177-83. doi: 10.1111/j.1365-2893.2011.01498.x. Epub 2011 Oct 7
Seroepidemiology and Molecular Characterization of Hepatitis E Virus in Macaca Mulatta from a Village in Yunnan, China, where Infection with this Virus Is Endemic.
Huang F, Yu W, Hua X, Jing S, Zeng W, He Z.
Hepat Mon. 2011 Sep 1;11(9):745-9
Hepatitis E virus-specific T-cell response after transplantation.
Kamar N, Legrand-Abravanel F, Dalton HR, Izopet J.
Hepatology. 2012 Jan 11. doi: 10.1002/hep.25578. [Epub ahead of print] No abstract available.
Hepatitis E: Global health burden of hepatitis E virus infection estimated.
[No authors listed]
Nat Rev Gastroenterol Hepatol. 2012 Jan 10. doi: 10.1038/nrgastro.2011.253. [Epub ahead of print] No abstract available.
Hepatitis E - an unexpected problem at home.
Cheung M, Maguire J, Carey I, Wendon J, Agarwal K.
Scand J Gastroenterol. 2012 Feb;47(2):253. Epub 2012 Jan 10. No abstract available.
Emerging and Re-emerging Swine Viruses.
Meng XJ.
Transbound Emerg Dis. 2012 Jan 9. doi: 10.1111/j.1865-1682.2011.01291.x. [Epub ahead of print
Hepatitis e virus infection in macaca mulatta.
Dastgerdi ES, Amini-Bavil-Olyaee S.
Hepat Mon. 2011 Oct 1;11(10):852-3. No abstract available.
Occurrence of hepatitis E virus RNA in plasma donations from Sweden, Germany and the United States.
Baylis SA, Gärtner T, Nick S, Ovemyr J, Blümel J.
Vox Sang. 2012 Jan 6. doi: 10.1111/j.1423-0410.2011.01583.x. [Epub ahead of print] No abstract available.
Hepatitis E virus in Norway rats (Rattus norvegicus) captured around pig farm.
Kanai Y, Miyasaka S, Uyama S, Kawami S, Kato-Mori Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K.
BMC Res Notes. 2012 Jan 5;5(1):4. [Epub ahead of print
Hepatitis E: Epidemiology and prevention.
Teshale EH, Hu DJ.
World J Hepatol. 2011 Dec 27;3(12):285-91
Chronic hepatitis E in hematopoietic stem cell transplant patients in a low-endemic country?
Koenecke C, Pischke S, Heim A, Raggub L, Bremer B, Raupach R, Buchholz S, Schulz T, Manns MP, Ganser A, Wedemeyer H.
Transpl Infect Dis. 2011 Dec 28. doi: 10.1111/j.1399-3062.2011.00702.x. [Epub ahead of print
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