Diseases

Brucellosis

Brucellosis is caused by the bacteria B. abortusD (from cattle), B. melitensis, B.ovis (from sheep, and goats), B. suis (pigs), and rarely B. canis (from dogs). Commonly transmitted through abrasions of the skin from handling infected mammals, or by by ingesting contaminated milk and dairy products.

Manifestation:

In the acute form (<8 weeks from illness onset), symptomatic, nonspecific and "flu-like," including:

• Fever
• Sweats
• Malaise
• Anorexia
• Headache
• Myalgia
• Back pain.

In the undulant form (<1 year from illness onset), symptoms include:

• undulant fevers
• arthritis
• orchiepididymitis in males.
• Neurologic symptoms may occur acutely in up to 5% of cases.

In the chronic form (>1 year from onset), symptoms may include:

• chronic fatigue syndrome-like
• depressive episodes
• Arthritis.

Diagnose and treatment: Diagnose is demonstrated by bloodtest. Therapy with antibiotics is available.

Prevent Brucellosis by

• Don’t drink unpasteurised milk
• Don’t eat dairy products from unpasteurised milk
• Don’t handle infected mammal.

Brucellosis Resource:

Brucella endocarditis: an occupational hazard!
Agarwal SK, Rajani AR, Hussain K, Dande MM.
BMJ Case Rep. 2013 Apr 22;2013. doi:pii: bcr2013009163. 10.1136/bcr-2013-009163
High-Risk Regions of Human Brucellosis in China: Implications for Prevention and Early Diagnosis of Travel Related Infections.
Chen Z, Zhang W, Ke Y, Wang Y, Tian B, Wang D, Cui B, Zou W, Li S, Huang L, Song H.
Clin Infect Dis. 2013 Apr 17. [Epub ahead of print] No abstract available.
Evaluation of the immunogenicity and the protective efficacy in mice of a DNA vaccine encoding SP41 from Brucella melitensis.
Al-Mariri A, Abbady AQ.
J Infect Dev Ctries. 2013 Apr 17;7(4):329-37. doi: 10.3855/jidc.2296
Congenital Brucellosis in an Infant.
Cacace ML, Claros EA, Erazu KA, Escobar GI, Lucero NE.
Vector Borne Zoonotic Dis. 2013 Apr 16. [Epub ahead of print
Within-host evolution of Brucella canis during a canine brucellosis outbreak in a kennel.
Gyuranecz M, Rannals BD, Allen CA, Jánosi S, Keim PS, Foster JT.
BMC Vet Res. 2013 Apr 12;9(1):76. [Epub ahead of print
Molecular Strain Typing of Brucella abortus Isolates from Italy by Two VNTR Allele Sizing Technologies.
De Santis R, Ancora M, De Massis F, Ciammaruconi A, Zilli K, Di Giannatale E, Pittiglio V, Fillo S, Lista F.
Mol Biotechnol. 2013 Apr 14. [Epub ahead of print
Ocular involvement of brucellosis.
Bazzazi N, Yavarikia A, Keramat F.
Middle East Afr J Ophthalmol. 2013 Jan;20(1):95-7. doi: 10.4103/0974-9233.106407
Splenic abscess due to acute brucellosis.
Deveer M, Sozen H, Cullu N, Sivrioglu AK.
BMJ Case Rep. 2013 Apr 10;2013. doi:pii: bcr2012008485. 10.1136/bcr-2012-008485
Levels of interleukin-(IL)-12p40 are markedly increased in brucellosis among patients with specific IL-12B genotypes.
Eskandari-Nasab E, Moghadampour M, Asadi-Saghandi A, Kharazi-Nejad E, Rezaeifar A, Pourmasoumi H.
Scand J Immunol. 2013 Apr 12. doi: 10.1111/sji.12054. [Epub ahead of print
Anything rare is possible here: Brucellosis in London in 2012.
Javaid MR, Farrugia M, Noeman Ahmed Y.
BMJ Case Rep. 2013 Apr 9;2013. doi:pii: bcr2013009178. 10.1136/bcr-2013-009178
A protein A/G indirect enzyme-linked immunosorbent assay for the detection of anti-Brucella antibodies in Arctic wildlife.
Nymo IH, Godfroid J, Asbakk K, Larsen AK, das Neves CG, Rødven R, Tryland M.
J Vet Diagn Invest. 2013 Apr 9. [Epub ahead of print
Epidemiologic Relatedness between Brucella abortus Isolates from Livestock and Wildlife in South Korea.
Kim JY, Her M, Kang SI, Lee K, Lee HK, Jung SC.
J Wildl Dis. 2013 Apr;49(2):451-4. doi: 10.7589/2012-07-188
[Fever, leg swelling, coughing, and left upper quadrant pain in a 19-year-old woman.]
Fitzner S, Wohlfart J, Müller A, Stich A, Weiss T.
Internist (Berl). 2013 Apr 10. [Epub ahead of print] German.
[Immune response and reproductive consequences in experimentally infected ewes with Brucella ovis during late pregnancy].
Paolicchi FA, Nuñez M, Fiorentino MA, Malena RC, Trangoni M, Cravero S, Estein SM.
Rev Argent Microbiol. 2013 Jan-Mar;45(1):13-20. Spanish.
An Infant with Acute Brucellosis Presenting With Coombs-Positive Autoimmune Hemolytic Anemia: Is Breastfeeding Guilty for Transmission?
Apa H, Keskin S, Gülfidan G, Yaman Y, Devrim I.
Vector Borne Zoonotic Dis. 2013 Apr 5. [Epub ahead of print
Seroprevalence and Risk Factors Associated with Brucellosis as a Professional Hazard in Pakistan.
Ali S, Ali Q, Neubauer H, Melzer F, Elschner M, Khan I, Abatih EN, Ullah N, Irfan M, Akhter S.
Foodborne Pathog Dis. 2013 Apr 6. [Epub ahead of print
Important biology events and pathways in Brucella infection and implications for novel antibiotic drug targets.
Gao G, Xu J.
Crit Rev Eukaryot Gene Expr. 2013;23(1):65-76
Brucella virulence mechanisms and implications in novel vaccines and drugs.
Gao G, Wang Y, Chen Z, Xu X, Xu J.
Crit Rev Eukaryot Gene Expr. 2013;23(1):49-64
Feral swine brucellosis in the United States and prospective genomic techniques for disease epidemiology.
Leiser OP, Corn JL, Schmit BS, Keim PS, Foster JT.
Vet Microbiol. 2013 Mar 15. doi:pii: S0378-1135(13)00139-9. 10.1016/j.vetmic.2013.02.025. [Epub ahead of print
Evaluation of four hundred and forty seven brucellosis cases.
Kursun E, Turunc T, Demiroglu Y, Arslan H.
Intern Med. 2013;52(7):745-50. Epub 2013 Apr 1
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