Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5.
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Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5.
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Authors: Kalb SR Baudys J Webb RP Wright P Smith TJ Smith LA Fernández R Raphael BH Maslanka SE Pirkle JL Barr JR
Address: Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA.
Journal:
Publication:
botulinum neurotoxins (BoNTs) cause botulism by cleaving proteins necessary for nerve transmission. There are seven serotypes of BoNT, A-G, characterized by their response to antisera. Many serotypes are further distinguished into differing subtypes based on amino acid sequence, some of which result in functional differences. Our laboratory previously reported that all tested subtypes within each serotype have the same site of enzymatic activity. Recently, three new subtypes of BoNT/F; /F3, /F4, and /F5, were reported. Here, we report that BoNT/F5 cleaves substrate synaptobrevin-2 in a different location than the other BoNT/F subtypes, between (54)L and (55)E. This is the first report of cleavage of synaptobrevin-2 in this location.
Published by Elsevier B.V.
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