Different serum cytokine levels in chronic vs. acute Anisakis simplex sensitization-associated urticaria.
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Different serum cytokine levels in chronic vs. acute Anisakis simplex sensitization-associated urticaria.
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Authors: Daschner A Rodero M DE Frutos C Valls A Vega F Blanco C Cuéllar C
Address: Servicio de Alergia, Instituto de Investigación Sanitaria-Hospital Universitario de la Princesa, Diego de León, Madrid, Spain. alvarodaschner@gmail.com
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The knowledge on immune mechanisms of chronic urticaria (CU) at the cytokine level is widely scarce. We compared pro- and anti-inflammatory as well as Th1- and Th2-associated serum cytokine levels in two phenotypes of CU: associated with (CU+) and without (CU⁻) sensitization against Anisakis simplex, a ubiquitous fish parasite, that has been associated with acute urticaria in gastro-allergic anisakiasis (GAA) and with CU+. Thirteen CU+ and 19 CU⁻ patients were compared with 13 GAA patients and 15 control subjects for cytokines, measured by cytometric bead array. Urticaria activity score was positively correlated with IL-6 in CU⁻. Serum levels of IL-10 were lower in CU+ and CU⁻ with respect to the control group. Median IFN-γ was lower in all urticaria groups. Patients with previous parasitism by A. simplex displayed higher TGF-β levels than subjects without previous parasitism. The main finding was lower levels of IL-17 in CU+ with respect to GAA or controls, with a further tendency to even lower levels in CU⁻. Different urticaria phenotypes are associated with distinct serum cytokine levels.
© 2011 Blackwell Publishing Ltd.
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