Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger.

Authors: Sharma P Singh R
Address: Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India.
Journal:

Publication:

abstract

BACKGROUND:

Dichlorvos and lindane pesticide causes toxicity in animals including humans. ginger (Zingiber officinale) is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of pharmacological properties.

OBJECTIVE:

This study was designed to assess ameliorating effects of ginger juice in dichlorvos and lindane induced neurotoxicity in wistar rats.

MATERIALS AND METHODS:

Dichlorvos (8.8 mg/kg bw) and lindane (8.8 mg/kg bw) were orally administered alone as well as in combination to adult male and female wistar rats for 14 days followed by the post-treatment of ginger juice (100 mg/kg bw) for 14 days. Lipid peroxidation (LPO), reduced glutathione (GSH), and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), quinine reductase (QR), and protein level were measured to evaluate the toxicity of these pesticides in brain.

RESULTS:

Dichlorvos and lindane administration alone and in combination increased LPO and decreased the GSH level, SOD, CAT, GPx, GST, GR, QR activity, and protein. oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the toxicities induced by these pesticides. Post-treatment of ginger juice decreased LPO and increased the level of GSH, SOD, CAT, GPx, GST, GR, QR activity and protein in the brain of rats.

CONCLUSIONS:

The results indicated that dichlorovos and lindane induced tissue damage was ameliorated by ginger juice.

Related Articles
Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats.
Phytother Res. 2008
Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats.
Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD. Phytother Res. 2008 Jul; 22(7):902-6.
Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats.
Food Chem Toxicol. 2000
Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats.
Ahmed RS, Seth V, Pasha ST, Banerjee BD. Food Chem Toxicol. 2000 May; 38(5):443-50.
Ameliorative action of melatonin on oxidative damage induced by atrazine toxicity in rat erythrocytes.
Mol Cell Biochem. 2011
Ameliorative action of melatonin on oxidative damage induced by atrazine toxicity in rat erythrocytes.
Bhatti JS, Sidhu IP, Bhatti GK. Mol Cell Biochem. 2011 Jul; 353(1-2):139-49. Epub 2011 Mar 15.
Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer.
Clin Chim Acta. 2005
Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer.
Manju V, Nalini N. Clin Chim Acta. 2005 Aug; 358(1-2):60-7.
PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid.
Neurotoxicology. 2007
PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid.
Venkataraman P, Muthuvel R, Krishnamoorthy G, Arunkumar A, Sridhar M, Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran J. Neurotoxicology. 2007 May; 28(3):490-8. Epub 2006 Dec 1.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.