Detection of IgM and IgG antibodies to Chlamydophila pneumoniae in pediatric community-acquired lower respiratory tract infections.

Authors:
Address: Department of Microbiology, Maulana Azad Medical College, New Delhi, India. kumarsurinderdr@yahoo.com
Journal:

Publication:

abstract

CONTEXT:

Chlamydophila pneumoniae (C. pneumoniae) is an emerging infectious agent with a spectrum of clinical manifestations including lower and upper respiratory tract infections.

AIMS:

To investigate the role of C. pneumoniae in community-acquired lower respiratory tract infections (LRTIs) in children using serological tests.

SETTINGS AND DESIGN:

Two hundred children, age 2 months to 12 years, hospitalized for community-acquired LRTIs were investigated for C. pneumoniae etiology.

MATERIALS AND METHODS:

We investigated 200 children hospitalized for community-acquired LRTIs, using ELISA for detecting anti-C. pneumoniae IgM and IgG antibodies. The demographic, clinical and radiological findings for C. pneumoniae antibody positive and C. pneumoniae antibody negative cases were compared.

STATISTICAL ANALYSIS USED:

Data analysis was performed by Chi-square test and Fisher's exact tests using Epi Info (2002).

RESULTS:

Clinical and radiological findings in both the groups were comparable. Serological evidence of C. pneumoniae infection was observed in 12 (6%) patients; specific IgM antibodies were detected in 11 (91.67%; specific IgG antibodies in 1 (8.33%) patients, while 4-fold rise in C. pneumoniae IgG antibody titers were noted in none of the patients.

CONCLUSIONS:

C. pneumoniae has a role in community-acquired LRTIs, even in children aged < 5 years. Serological Detection using ELISA would enable pediatricians in better management of C. pneumoniae infections.

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