Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease.

Authors: Mohamed AE,Yasawy MI,Al Karawi MA,
Address: Department of Gastroenterology, Armed Forces Hospital, Riyadh, Saudi Arabia.
Journal: Hepatogastroenterology.

Publication: 1998 Sep-Oct;45(23):1690-4.

abstract

BACKGROUND/AIMS:

This study was conducted to evaluate the effect of different regimens of medical treatment in hydatid disease at the Armed Forces Hospital, Riyadh.

METHODOLOGY:

Between April 1985 and August 1990 albendazole was used alone in the treatment of 22 patients with hydatid disease, mainly of the liver. Since September 1990, we have used a combination treatment of albendazole and praziquantel in 19 patients.

RESULTS:

For those patients treated only with albendazole, 8 patients (36.4%) showed a complete disappearance of the cyst, in 4 of which the treatment period ranged between 6 months to 2 years. The other 4 patients had ruptured liver cyst into biliary tree and had endoscopic treatment with complete recovery over a short period. For those patients treated with albendazole and praziquantel the following results were found. During a follow-up period of 2 months to 3 years and a treatment period of only 2-6 months there was complete disappearance of the hydatid cyst in 9 patients (47.4%) and over 50% reduction of the hydatid cyst in 5 patients (36.84%).

CONCLUSION:

Combination treatment with albendazole and praziquantel for hydatid disease is more effective than albendazole alone.

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