A proportional increase in candidemia due to non-albicans Candida species has been reported worldwide. In our hospital, 36 of 58 candidemia cases were caused by non-albicans Candida species between 1996 and 2007. Candidemia due to non-albicans Candida species is associated with fluconazole(FLCZ)exposure. In our cases, 36 of 36 non-albicans candidemia cases received FLCZ while 18 of 22 albicans candidemia cases received this drug. In general, non-albicans Candida species including C. tropicalis, C. parapsilosis, and C. guilliermondii are susceptible to FLCZ. On the other hand, C. glabrata and C. krusei exhibit decreased susceptibility to FLCZ. Our in vitro susceptibility test revealed the same results as above although C. guilliermondii showed an elevated MIC to FLCZ(4-8 microg/ml). In addition, both C. parapsilosis and C. guilliermondii showed elevated MICs to micafungin (1 microg/ml and 0.5-2 microg/ml, respectively) which is generally useful for non-albicans Candida species.
Related ArticlesInternational surveillance of bloodstream infections due to Candida species: frequency of occurrence and antifungal susceptibilities of isolates collected in 1997 in the United States, Canada, and South America for the SENTRY Program. The SENTRY Participant Group.J Clin Microbiol. 1998
International surveillance of bloodstream infections due to Candida species: frequency of occurrence and antifungal susceptibilities of isolates collected in 1997 in the United States, Canada, and South America for the SENTRY Program. The SENTRY Participant Group.
Pfaller MA, Jones RN, Doern GV, Sader HS, Hollis RJ, Messer SA. J Clin Microbiol. 1998 Jul; 36(7):1886-9.
[Antifungal susceptibility of Candida species causing candidemia in Kurume University Hospital and Shaiseikai Hutukaichi Hospital].Kansenshogaku Zasshi. 2005
[Antifungal susceptibility of Candida species causing candidemia in Kurume University Hospital and Shaiseikai Hutukaichi Hospital].
Rikimaru T, Yonemitu J, Shimada A, Koga A, Nishiyama M, Hashimoto K, Tanamachi C, Fujimoto K, Sagawa K, Aizawa H. Kansenshogaku Zasshi. 2005 Jan; 79(1):20-4.
International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program.J Clin Microbiol. 2001
International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program.
Pfaller MA, Diekema DJ, Jones RN, Sader HS, Fluit AC, Hollis RJ, Messer SA, SENTRY Participant Group. J Clin Microbiol. 2001 Sep; 39(9):3254-9.
Review Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance.J Hosp Infect. 2002
Review Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance.
Krcmery V, Barnes AJ. J Hosp Infect. 2002 Apr; 50(4):243-60.
Review Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria.Drug Resist Updat. 2011
Review Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria.
Pfaller MA, Diekema DJ, Andes D, Arendrup MC, Brown SD, Lockhart SR, Motyl M, Perlin DS, CLSI Subcommittee for Antifungal Testing. Drug Resist Updat. 2011 Jun; 14(3):164-76. Epub 2011 Feb 24.
To
top
•
Home
Show
map | Diseases | Vaccination
| Chronic disease | Medicine
| Pregnancy
| Heat & Sunburn | Cold | Security
| Useful tips | Faq
| News
TraveldoctorOnline 2001 •
Disclaimer • webmaster
