Behçet's syndrome and micro-organisms.

Authors: Hatemi G,Yazici H,
Address: Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey. gulenhatemi@yahoo.com
Journal: Best Pract Res Clin Rheumatol.

Publication: 2011 Jun;25(3):389-406. doi: 10.1016/j.berh.2011.05.002.

abstract

Behçet's syndrome (BS) is a multi-systemic vasculitis of unknown aetiology. More than one mechanism seems to be operative in the pathogenesis of Behçet's syndrome, including genetic and environmental factors, causing different manifestations of the syndrome. There are several clues to the role of environmental factors and especially micro-organisms in the pathogenesis. These include clinical findings such as a decrease in the frequency of a positive pathergy reaction with surgical cleaning of the skin before the procedure, the acne-arthritis association carrying similar features to acne-associated reactive arthritis, a higher rate of tonsillectomy, cold sores, late birth order, higher number of siblings, history of travel to countries with a high incidence of BS and earlier age at first sexual intercourse. Moreover, basic research on both viruses and bacteria suggests that micro-organisms may be playing a role, possibly through heat shock proteins and T-cell hypersensitivity.

Related Articles
The significance of immunohistochemistry in the skin pathergy reaction of patients with Behçet's syndrome.
J Eur Acad Dermatol Venereol. 2004
The significance of immunohistochemistry in the skin pathergy reaction of patients with Behçet's syndrome.
Inaloz HS, Evereklioglu C, Unal B, Kirtak N, Eralp A, Inaloz SS. J Eur Acad Dermatol Venereol. 2004 Jan; 18(1):56-61.
Is Behçet's disease triggered by childhood infection?
Ann Rheum Dis. 1989
Is Behçet's disease triggered by childhood infection?
Cooper C, Pippard EC, Sharp H, Wickham C, Chamberlain MA, Barker DJ. Ann Rheum Dis. 1989 May; 48(5):421-3.
[Acute psychosis and Behçet's disease: a case report].
Encephale. 2006
[Acute psychosis and Behçet's disease: a case report].
Nkam I, Cottereau MJ. Encephale. 2006 May-Jun; 32(3 Pt 1):385-8.
Review Behçet's syndrome: disease manifestations, management, and advances in treatment.
Nat Clin Pract Rheumatol. 2007
Review Behçet's syndrome: disease manifestations, management, and advances in treatment.
Yazici H, Fresko I, Yurdakul S. Nat Clin Pract Rheumatol. 2007 Mar; 3(3):148-55.
Review Behçet's syndrome. The Cerrahpasa experience. Members of the Behçet's Syndrome Research Centre.
Adv Exp Med Biol. 1999
Review Behçet's syndrome. The Cerrahpasa experience. Members of the Behçet's Syndrome Research Centre.
Yazici H, Fresko I, Hamuryudan V, Mat C, Melikoglu M, Ozyazgan Y, Tuzun Y, Yurdakul S. Adv Exp Med Biol. 1999; 455:135-40.
Persistent fever, neck swelling, and small vessel vasculitis following tonsillectomy in a patient with Behçet's disease: a case report.
J Med Case Rep. 2012
Persistent fever, neck swelling, and small vessel vasculitis following tonsillectomy in a patient with Behçet's disease: a case report.
Wagner C, Schär D, Tinguely M, Kunz I. J Med Case Rep. 2012 Oct 30; 6(1):371. Epub 2012 Oct 30.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.