Hepatitis B vaccination and liver cancer mortality reduction in Korean children and adolescents.

Authors: Gwack J Park SK Lee EH Park B Choi Y Yoo KY
Address: Division of Epidemic Intelligence Service, Korea Center for Disease Control and Prevention, Osong, Korea.
Journal:

Publication:

abstract

liver cancer is one of the three most common causes of cancer mortality in the world and it is closely related to chronic Hepatitis B viral (HBV) infection in Korea. The decline of HBV prevalence for the last two decades in Korea might be partly due to the HBV vaccination, which was implemented as a national program starting in 1995. The aim of this study was to assess the period effect of the national HBV vaccination on liver cancer mortality in a young population. We compared age-specific mortality rates of liver cancer before and after the national vaccination program in the Korean population under the age of 20. To reduce year-to-year fluctuations in mortality, calendar years and age groups were divided into 4-year strata and the mortality rates were calculated for each stratum. Period effects of the national vaccination program were analyzed using age-period-cohort modeling. A total of 370 liver cancer mortality cases were identified during the period from 1991 to 2006. The period effect of the national vaccination program for the period 2002-2006 had a significantly reduced liver cancer mortality rate when compared to the period 1991-1994 when the national vaccination program was not implemented (RR 0.30, 95% CI 0.21~0.44). After implementation of the national vaccination program, HBV prevalence in Korean declined from 6~8% to 2~3%. This study demonstrates that the national vaccination program has contributed to the reduction of liver cancer mortality beyond just a natural decrease in Korean children and adolescents.

Related Articles
Surveillance for acute viral hepatitis - United States, 2007.
MMWR Surveill Summ. 2009
Surveillance for acute viral hepatitis - United States, 2007.
Daniels D, Grytdal S, Wasley A, Centers for Disease Control and Prevention (CDC). MMWR Surveill Summ. 2009 May 22; 58(3):1-27.
Final Report on Carcinogens Background Document for Formaldehyde.
Rep Carcinog Backgr Doc. 2010
Final Report on Carcinogens Background Document for Formaldehyde.
National Toxicology Program. Rep Carcinog Backgr Doc. 2010 Jan; (10-5981):i-512.
[Tuberculosis in Iceland. 1976].
Laeknabladid. 2005
[Tuberculosis in Iceland. 1976].
Sigurdsson S. Laeknabladid. 2005 Jan; 91(1):69-102.
Review Impacts of vaccination on hepatitis B viral infections in Korea over a 25-year period.
Intervirology. 2010
Review Impacts of vaccination on hepatitis B viral infections in Korea over a 25-year period.
Park NH, Chung YH, Lee HS. Intervirology. 2010; 53(1):20-8. Epub 2010 Jan 5.
Review Cancer prevention by vaccination against hepatitis B.
Recent Results Cancer Res. 2009
Review Cancer prevention by vaccination against hepatitis B.
Chang MH. Recent Results Cancer Res. 2009; 181:85-94.

To top • Home

TraveldoctorOnline 2001 • Disclaimer • webmaster

The contents within traveldoctoronline are presented only for informational purposes and cannot substitute for professional health care or any other medical treatment.All users of this website with health problems should be oblige always to consult their medical doctor before starting any treatment.