Useful tips

Air Travel and Comfort

Although aircraft cabins are pressurized, cabin air pressure at cruising altitude is lower than air pressure at sea level. At a typical cruising altitude of 11 000 metres (37 000 feet), air pressure in the cabin is equivalent to that at an altitude of 1500?500 metres (5000?000 feet) above sea level. 

As a consequence, the available oxygen is reduced and gases within the body expand why it is recommended to:

Prolonged immobility, particularly when the individual is seated, leads to pooling of blood in the legs, which in turn causes swelling, stiffness, and discomfort.
Circulatory stasis is a predisposing factor for the development of venous thrombosis (blood clots). Flex thoroughly when you are awake.

Air travel and comfort Resource:

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